Keramat Laleh, Sadrzadeh-Yeganeh Haleh, Sotoudeh Gity, Zamani Elham, Eshraghian Mohammadreza, Mansoori Anahita, Koohdani Fariba
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Nutrition. 2017 May;37:86-91. doi: 10.1016/j.nut.2016.12.012. Epub 2016 Dec 28.
Several investigations have been conducted regarding the interaction between Apolipoprotein A2 (APOA2) -265 T>C polymorphism and dietary intake of saturated fatty acids (SFAs) on obesity in healthy individuals or type 2 diabetes mellitus (T2 DM) patients. The aim of the present study is to examine the effect of this interaction on inflammatory markers in T2 DM patients.
This is a comparative cross-sectional study on 180 T2 DM patients with known APOA2 genotype. Dietary intake was assessed by food-frequency questionnaire and serum levels of inflammatory markers (interleukin [IL]-18, pentraxin 3, and high-sensitivity C-reactive protein [hs-CRP]) were measured. The subjects were dichotomized into "high" and "low" categories, based on the median dietary intake of polyunsaturated fatty acids (PUFAs), monounsaturated fatty acids (MUFAs), and SFAs. The data were analyzed by analysis of covariance multivariate interaction model.
In CC genotype, higher median intake of ω-3 PUFAs and MUFAs was associated with decreased serum levels of IL-18 and hs-CRP (P = 0.014 and 0.008, respectively). In T-allele carriers, higher median intake of SFAs was associated with increased serum hs-CRP level (P < 0.001). There was a significant relationship between APOA2 polymorphism and ω-3 PUFA intake on serum IL-18 level (P interaction = 0.03). Moreover, the relationship between this polymorphism and SFA and MUFA intake on serum hs-CRP level was statistically significant (P interaction = 0.03 and 0.024, respectively).
In T2 DM patients, the dietary intake of antiinflammatory fatty acids, such as ω-3 PUFAs and MUFAs, could reduce the inflammatory effects associated with the CC genotype. In addition, proinflammatory fatty acids, such as SFAs, could overcome the antiinflammatory effect of the T-allele. Further studies are needed to confirm these findings.
针对载脂蛋白A2（APOA2）-265 T>C多态性与饱和脂肪酸（SFA）饮食摄入量对健康个体或2型糖尿病（T2 DM）患者肥胖的相互作用，已开展了多项研究。本研究旨在探讨这种相互作用对T2 DM患者炎症标志物的影响。
这是一项针对180例已知APOA2基因型的T2 DM患者的比较性横断面研究。通过食物频率问卷评估饮食摄入量，并测量炎症标志物（白细胞介素[IL]-18、五聚素3和高敏C反应蛋白[hs-CRP]）的血清水平。根据多不饱和脂肪酸（PUFA）、单不饱和脂肪酸（MUFA）和SFA的饮食摄入量中位数，将受试者分为“高”和“低”两类。采用协方差分析多元相互作用模型对数据进行分析。
在CC基因型中，ω-3 PUFA和MUFA的较高摄入量中位数与IL-18和hs-CRP血清水平降低相关（分别为P = 0.014和0.008）。在T等位基因携带者中，SFA的较高摄入量中位数与血清hs-CRP水平升高相关（P < 0.001）。APOA2多态性与ω-3 PUFA摄入量对血清IL-18水平有显著关系（P相互作用 = 0.03）。此外，这种多态性与SFA和MUFA摄入量对血清hs-CRP水平的关系具有统计学意义（P相互作用分别为0.03和0.024）。
在T2 DM患者中，抗炎脂肪酸如ω-3 PUFA和MUFA的饮食摄入可降低与CC基因型相关的炎症作用。此外，促炎脂肪酸如SFA可克服T等位基因的抗炎作用。需要进一步研究来证实这些发现。
