• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Sphingosine kinase 1 participates in the activation, proliferation and survival of chronic lymphocytic leukemia cells.

作者信息

Almejún María Belén, Borge Mercedes, Colado Ana, Elías Esteban Enrique, Podaza Enrique, Risnik Denise, De Brasi Carlos Daniel, Stanganelli Carmen, Slavutsky Irma, Cabrejo María, Fernández-Grecco Horacio, Bezares Raimundo Fernando, Cranco Santiago, Burgos Rubén Ángel, Sánchez-Ávalos Julio César, Oppezzo Pablo, Giordano Mirta, Gamberale Romina

机构信息

Laboratorio de Inmunología Oncológica, Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina (ANM), Buenos Aires, Argentina.

Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.

出版信息

Haematologica. 2017 Jul;102(7):e257-e260. doi: 10.3324/haematol.2017.167353. Epub 2017 Mar 30.

DOI:10.3324/haematol.2017.167353
PMID:28360148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5566050/
Abstract
摘要

相似文献

1
Sphingosine kinase 1 participates in the activation, proliferation and survival of chronic lymphocytic leukemia cells.鞘氨醇激酶1参与慢性淋巴细胞白血病细胞的激活、增殖和存活。
Haematologica. 2017 Jul;102(7):e257-e260. doi: 10.3324/haematol.2017.167353. Epub 2017 Mar 30.
2
Angiopoietin-2 acts as a survival factor for chronic lymphocytic leukemia B cells throughout Tie-2 receptor engagement.血管生成素-2通过与Tie-2受体结合，作为慢性淋巴细胞白血病B细胞的存活因子。
Hematol Oncol. 2018 Feb;36(1):372-375. doi: 10.1002/hon.2448. Epub 2017 Jun 4.
3
SphK1 inhibitor potentiates the anti-cancer effect of EGCG on leukaemia cells.
Br J Haematol. 2017 Jul;178(1):155-158. doi: 10.1111/bjh.14119. Epub 2016 May 25.
4
Lenalidomide interferes with tumor-promoting properties of nurse-like cells in chronic lymphocytic leukemia.来那度胺可干扰慢性淋巴细胞白血病中类成纤维细胞的促肿瘤特性。
Haematologica. 2015 Feb;100(2):253-62. doi: 10.3324/haematol.2014.113217. Epub 2014 Nov 14.
5
SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course.SLP76整合到慢性淋巴细胞白血病细胞的B细胞受体信号级联反应中，并与侵袭性病程相关。
Haematologica. 2016 Dec;101(12):1553-1562. doi: 10.3324/haematol.2015.139154. Epub 2016 Jul 21.
6
Expression of a truncated B lymphocyte-induced maturation protein-1 isoform is associated with an incomplete plasmacytic differentiation program in chronic lymphocytic leukemia.
Leuk Lymphoma. 2018 Feb;59(2):482-485. doi: 10.1080/10428194.2017.1330470. Epub 2017 Jun 2.
7
Inhibition of BCR signaling using the Syk inhibitor TAK-659 prevents stroma-mediated signaling in chronic lymphocytic leukemia cells.使用Syk抑制剂TAK-659抑制BCR信号传导可防止慢性淋巴细胞白血病细胞中的基质介导信号传导。
Oncotarget. 2017 Jan 3;8(1):742-756. doi: 10.18632/oncotarget.13557.
8
Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B-cell activation and proliferation.滤泡树突状细胞的进入是小鼠慢性淋巴细胞白血病 B 细胞激活和增殖的关键步骤。
Cancer Discov. 2014 Dec;4(12):1448-65. doi: 10.1158/2159-8290.CD-14-0096. Epub 2014 Sep 24.
9
Idelalisib impairs T-cell-mediated immunity in chronic lymphocytic leukemia.idelalisib损害慢性淋巴细胞白血病中T细胞介导的免疫。
Haematologica. 2018 Dec;103(12):e598-e601. doi: 10.3324/haematol.2017.187070. Epub 2018 Jul 5.
10
Altered expression pattern of SLAM family receptors on pathological B cells of patients with chronic lymphocytic leukemia.慢性淋巴细胞白血病患者病理性B细胞上信号淋巴细胞激活分子家族受体的表达模式改变。
Leuk Lymphoma. 2017 Jul;58(7):1726-1729. doi: 10.1080/10428194.2016.1251593. Epub 2016 Nov 21.

引用本文的文献

1
Is Sphingosine Kinase 1 Associated with Hematological Malignancy? A Systematic Review and Meta-Analysis.丝氨酸棕榈酰转移酶 1 与血液系统恶性肿瘤有关吗？系统评价和荟萃分析。
Asian Pac J Cancer Prev. 2024 Aug 1;25(8):2605-2613. doi: 10.31557/APJCP.2024.25.8.2605.
2
Targeting sphingolipid metabolism in chronic lymphocytic leukemia.靶向慢性淋巴细胞白血病中的鞘脂代谢。
Clin Exp Med. 2024 Jul 30;24(1):174. doi: 10.1007/s10238-024-01440-x.
3
Role of Glycolytic and Glutamine Metabolism Reprogramming on the Proliferation, Invasion, and Apoptosis Resistance through Modulation of Signaling Pathways in Glioblastoma.糖酵解和谷氨酰胺代谢重编程通过调节信号通路在胶质母细胞瘤中的增殖、侵袭和抗凋亡作用。
Int J Mol Sci. 2023 Dec 18;24(24):17633. doi: 10.3390/ijms242417633.
4
Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer.癌症中通过碳水化合物和脂质代谢对自噬的调控
Cancers (Basel). 2023 Apr 7;15(8):2195. doi: 10.3390/cancers15082195.
5
Venetoclax resistance induced by activated T cells can be counteracted by sphingosine kinase inhibitors in chronic lymphocytic leukemia.在慢性淋巴细胞白血病中，鞘氨醇激酶抑制剂可对抗由活化T细胞诱导的维奈托克耐药。
Front Oncol. 2023 Mar 20;13:1143881. doi: 10.3389/fonc.2023.1143881. eCollection 2023.
6
Immunomodulatory effects of different intravenous immunoglobulin preparations in chronic lymphocytic leukemia.不同静脉注射免疫球蛋白制剂在慢性淋巴细胞白血病中的免疫调节作用。
Sci Rep. 2021 Jun 21;11(1):12926. doi: 10.1038/s41598-021-92412-8.
7
The Tumorigenic Effect of Sphingosine Kinase 1 and Its Potential Therapeutic Target.鞘氨醇激酶 1 的致瘤作用及其潜在的治疗靶点。
Cancer Control. 2020 Jan-Dec;27(1):1073274820976664. doi: 10.1177/1073274820976664.
8
Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells.鞘氨醇激酶1/细胞外信号调节激酶/磷酸化细胞外信号调节激酶通路的激活促进结肠癌细胞的自噬。
Oncol Lett. 2018 Jun;15(6):9719-9724. doi: 10.3892/ol.2018.8588. Epub 2018 Apr 26.

本文引用的文献

1
Sphingosine-1 Phosphate: A New Modulator of Immune Plasticity in the Tumor Microenvironment.鞘氨醇-1-磷酸：肿瘤微环境中免疫可塑性的新型调节剂。
Front Oncol. 2016 Oct 17;6:218. doi: 10.3389/fonc.2016.00218. eCollection 2016.
2
The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway.鞘氨醇-1-磷酸调节剂 FTY720 通过 CXCR4/CXCL12 途径靶向多发性骨髓瘤。
Clin Cancer Res. 2017 Apr 1;23(7):1733-1747. doi: 10.1158/1078-0432.CCR-15-2618. Epub 2016 Oct 3.
3
Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.靶向鞘氨醇激酶和鞘氨醇 1-磷酸在血液系统恶性肿瘤中的治疗潜力。
Leukemia. 2016 Nov;30(11):2142-2151. doi: 10.1038/leu.2016.208. Epub 2016 Jul 27.
4
SphK1 inhibitor potentiates the anti-cancer effect of EGCG on leukaemia cells.
Br J Haematol. 2017 Jul;178(1):155-158. doi: 10.1111/bjh.14119. Epub 2016 May 25.
5
Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism.溶酶体靶向药物由于鞘脂代谢改变而选择性地靶向慢性淋巴细胞白血病细胞。
Leukemia. 2016 Jun;30(6):1290-300. doi: 10.1038/leu.2016.4. Epub 2015 Feb 23.
6
Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.鞘氨醇激酶抑制剂可降低自然杀伤大颗粒淋巴细胞白血病的细胞活力并诱导细胞死亡。
Cancer Biol Ther. 2015;16(12):1830-40. doi: 10.1080/15384047.2015.1078949.
7
SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo.鞘氨醇激酶1抑制剂II（SKI-II）在体外和体内均能抑制急性髓性白血病细胞的生长。
Biochem Biophys Res Commun. 2015 May 15;460(4):903-8. doi: 10.1016/j.bbrc.2015.03.114. Epub 2015 Mar 28.
8
Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy.重新审视鞘脂变阻器：癌症治疗中的不断演变的概念。
Exp Cell Res. 2015 May 1;333(2):195-200. doi: 10.1016/j.yexcr.2015.02.025. Epub 2015 Mar 11.
9
A sphingosine kinase-1 inhibitor, SKI-II, induces growth inhibition and apoptosis in human gastric cancer cells.一种鞘氨醇激酶-1抑制剂SKI-II可诱导人胃癌细胞生长抑制和凋亡。
Asian Pac J Cancer Prev. 2014;15(23):10381-5. doi: 10.7314/apjcp.2014.15.23.10381.
10
The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406.慢性淋巴细胞白血病细胞中鞘氨醇-1-磷酸受体-1的表达受到肿瘤微环境信号的损害，并被白皮杉醇和R406增强。
J Immunol. 2014 Sep 15;193(6):3165-74. doi: 10.4049/jimmunol.1400547. Epub 2014 Aug 15.