Hilbert Anja, Petroff David, Herpertz Stephan, Kersting Anette, Pietrowsky Reinhard, Tuschen-Caffier Brunna, Vocks Silja, Schmidt Ricarda
Department of Medical Psychology and Medical Sociology, Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany.
Clinical Trial Center Leipzig, University of Leipzig, Leipzig, Germany.
BMJ Open. 2017 Mar 29;7(3):e013655. doi: 10.1136/bmjopen-2016-013655.
Binge-eating disorder (BED) was included as its own diagnostic entity in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). An increasing number of treatment studies have been published, but an up-to-date comprehensive meta-analysis on diverse treatment approaches for BED is lacking. In an updated and extension of a previous meta-analysis, the goals of this study are to assess the short-term and long-term effectiveness of psychological and medical treatments for BED.
We will search bibliographic databases and study registries, including manual searches for studies published before January 2016. The search strategy will include terms relating to binge eating and diverse forms of psychological and medical interventions. Language will be restricted to English. The studies included will be treatment studies, that is, randomised-controlled trials, and non-randomised and non-controlled studies, for individuals with BED (DSM-IV or DSM-5), and studies that provided a pre-treatment and at least one post-treatment or follow-up assessment of binge eating. The primary outcomes will be the number of binge-eating episodes, abstinence from binge eating and diagnosis of BED at post-treatment and/or follow-up(s), and changes from pre-treatment to post-treatment and/or follow-up(s). Likewise, as secondary outcomes, eating disorder and general psychopathology, quality of life, and body weight will be analysed and adverse events and treatment drop-out will be examined. Study search, selection and data extraction, including risk of bias assessment, will be independently performed by 2 reviewers and consensus will be sought. Moderator analyses will be conducted, and equity aspects will be considered. Sensitivity analyses will be conducted to determine the robustness of the results.
Ethical approval is not required for this meta-analysis. Published in a peer-reviewed journal and disseminated electronically and in print, this meta-analysis will form the basis of the renewal of the German evidence-based S3 Guidelines of Diagnosis and Treatment of Eating Disorders, specifically BED.
CRD42016043604.
暴食症（BED）在《精神疾病诊断与统计手册》第五版（DSM-5）中被列为一种独立的诊断实体。越来越多的治疗研究已发表，但缺乏针对暴食症不同治疗方法的最新综合荟萃分析。在对先前荟萃分析的更新和扩展中，本研究的目的是评估针对暴食症的心理和药物治疗的短期和长期效果。
我们将检索文献数据库和研究注册库，包括手动检索2016年1月之前发表的研究。检索策略将包括与暴饮暴食以及各种心理和药物干预形式相关的术语。语言将限于英语。纳入的研究将是针对患有暴食症（DSM-IV或DSM-5）的个体的治疗研究，即随机对照试验、非随机和非对照研究，以及提供了暴饮暴食的治疗前和至少一次治疗后或随访评估的研究。主要结局将是治疗后和/或随访时的暴饮暴食发作次数、停止暴饮暴食情况和暴食症诊断，以及从治疗前到治疗后和/或随访时的变化。同样，作为次要结局，将分析饮食失调和一般精神病理学、生活质量和体重，并检查不良事件和治疗退出情况。研究检索、选择和数据提取，包括偏倚风险评估，将由2名评审员独立进行，并寻求共识。将进行调节分析，并考虑公平性方面。将进行敏感性分析以确定结果的稳健性。
本荟萃分析无需伦理批准。该荟萃分析将发表在同行评审期刊上，并以电子和印刷形式传播，将构成德国基于证据的饮食失调（特别是暴食症）诊断和治疗S3指南更新的基础。
CRD42016043604。
