Bülbül Feridun, Eryiğit Ayşegül Giray, Erbağci A Binnur, Selek Salih, Savaş Haluk
Department of Psychiatry, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.
Department of Biochemistry, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.
Noro Psikiyatr Ars. 2014 Mar;51(1):52-56. doi: 10.4274/npa.y6668. Epub 2014 Mar 1.
Obesity is more common among patients with bipolar disorder as compared to normal population. There are studies showing increased leptin levels in obese patients. The aim of the present study was to investigate the alterations in leptin levels, body mass index (BMI), and lipid-lipoprotein levels during manic period, as well as during euthymic period, after one month in patients with bipolar disorder.
Thirty-one adult patients, who had been hospitalized in the psychiatry clinic because of manic period of bipolar disorder, were included in the present study. Serum leptin and lipid-lipoprotein levels and BMI of the patients were analyzed both on the first day and 30th day of hospitalization after they became euthymic.
Total cholesterol and triglyceride levels significantly increased in male patients (p<.05). The increase in total cholesterol and LDL-C levels was not significant in female patients (p=.066 and p=.056, respectively). BMI was significantly, but slightly increased in both genders (.56±.14 kg/m), however, such a change was not observed in serum leptin levels.
Results of the present study demonstrated that clinical improvement in bipolar patients showed different association in each gender with the alterations in BMI and serum lipid and/or lipoprotein levels. Such an alteration might have resulted from direct or indirect effect of drugs, as well as from lifestyle changes.
与正常人群相比，肥胖在双相情感障碍患者中更为常见。有研究表明肥胖患者的瘦素水平升高。本研究的目的是调查双相情感障碍患者在躁狂期以及在心境正常期（住院一个月后）瘦素水平、体重指数（BMI）和脂质 - 脂蛋白水平的变化。
本研究纳入了31名因双相情感障碍躁狂期而入住精神科门诊的成年患者。在患者心境正常后，于住院第一天和第30天分析其血清瘦素、脂质 - 脂蛋白水平及BMI。
男性患者的总胆固醇和甘油三酯水平显著升高（p <.05）。女性患者的总胆固醇和低密度脂蛋白胆固醇（LDL - C）水平升高不显著（分别为p =.066和p =.056）。BMI在两性中均显著但略有升高（.56±.14 kg/m²），然而，血清瘦素水平未观察到此类变化。
本研究结果表明，双相情感障碍患者的临床改善在每种性别中与BMI以及血清脂质和/或脂蛋白水平的变化呈现不同的关联。这种变化可能是由药物的直接或间接作用以及生活方式的改变导致的。
