阻塞性睡眠呼吸暂停综合征患者的神经病变与自主神经功能障碍
Neuropathy and Dysautonomia in Patients with Obstructive Sleep Apnea Syndrome.
作者信息
Evlice Ahmet, Uğurel Burcu, Baklan Barış, Öztura İbrahim
机构信息
Department of Neurology, Çukurova University Faculty of Medicine, Adana, Turkey.
Department of Neurology, Yeditepe University Faculty of Medicine, İstanbul, Turkey.
出版信息
Noro Psikiyatr Ars. 2015 Mar;52(1):24-28. doi: 10.5152/npa.2015.7288. Epub 2015 Mar 1.
INTRODUCTION
The aim of our study is to search for the existence of neuropathy, dysautonomia and to identify the correlations of sickness level of patients with Obstructive Sleep Apnea Syndrome (OSAS).
METHODS
The research is based on the real cases at Dokuz Eylul University of Medicine Sleep and Epilepsy Center, observed during September 2008-May 2009. The patients were selected by polysomnography samples based on 20 persons at same ages with following criteria; high leveled OSAS (AHİ≥30), low OSAS (5≤AHİ<30) and healthy participants. Classical ENMG protocol, symphatic skin response and R-R interval variation test were performed on these samples.
RESULTS
High and low leveled OSAS patients had a statistically significant (p<0.05) decrease in the average velocity of motor conduction in right tibialis posterior when compared to the control group. Besides we observed an statistically significant (p<0.05) increase in the average amplitud of symphatic skin responses in high leveled OSAS patients than control group.
CONCLUSION
OSAS indicates a risk of possible peripheral neuropathy and autonomic dysfunction risk increases in positive correlation with level of OSAS.
引言
我们研究的目的是探寻神经病变、自主神经功能障碍的存在情况，并确定阻塞性睡眠呼吸暂停综合征（OSAS）患者疾病严重程度的相关性。
方法
该研究基于2008年9月至2009年5月期间在多库兹艾吕尔大学医学院睡眠与癫痫中心观察到的真实病例。通过多导睡眠图样本，按照以下标准从同年龄段的人群中选取患者：重度OSAS（呼吸暂停低通气指数[AHI]≥30）、轻度OSAS（5≤AHI<30）以及健康参与者。对这些样本进行经典的肌电图检查、交感皮肤反应和R-R间期变异性测试。
结果
与对照组相比，重度和轻度OSAS患者右侧胫后肌运动传导平均速度有统计学意义的降低（p<0.05）。此外，我们观察到重度OSAS患者的交感皮肤反应平均波幅比对照组有统计学意义的增加（p<0.05）。
结论
OSAS表明存在外周神经病变的风险，且自主神经功能障碍风险与OSAS严重程度呈正相关增加。
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