Mayda Hasan, Ahsen Ahmet, Bağcioğlu Erman, Öztürk Ahmet, Bahçeci Bülent, Soyuçok Etem, Başpinar Erol, Ulu Memnune Sena
Department of Psychiatry, Afyon Kocatepe University School of Medicine, Afyonkarahisar, Turkey.
Department of Internal Medicine, Afyon Kocatepe University School of Medicine, Afyonkarahisar, Turkey.
Noro Psikiyatr Ars. 2016 Dec;53(4):317-320. doi: 10.5152/npa.2016.10272. Epub 2016 Dec 1.
The neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) are simple, low-cost, and useful inflammatory markers detected in routine complete blood count (CBC), and their use has recently become widespread. In this study, we aimed to investigate the presence of an inflammatory state in manic patients on the basis of NLR and MPV values.
This retrospective study was performed on 76 patients with acute mania who were admitted to the Inpatients Psychiatry Clinic of Afyon Kocatepe University Hospital in Turkey. Diagnoses were based on Diagnostic and Statistical Manuel of Mental disorder (DSM-IV). The control group consisted of 74 healthy individuals recruited from the community. They were age- and sex-matched with the study group.
NLR values of the manic patient group were 2.2±1.4 and those of the control group were 1.6±0.5. NLR values were significantly higher (p=0.004) and MPV values were significantly lower in the manic patient group than in the control group (10.0±1.2 vs. 10.9±2.3, p=0.027).
Increased NLR and decreased MPV levels may reflect inflammation in manic patients, and inflammation may play a role in the complex pathophysiology of acute mania.
中性粒细胞与淋巴细胞比值（NLR）和平均血小板体积（MPV）是在常规全血细胞计数（CBC）中检测到的简单、低成本且有用的炎症标志物，它们的应用近来已广泛普及。在本研究中，我们旨在基于NLR和MPV值调查躁狂症患者体内炎症状态的存在情况。
本回顾性研究对土耳其阿菲永科泰佩大学医院住院精神科收治的76例急性躁狂症患者进行。诊断依据《精神疾病诊断与统计手册》（DSM-IV）。对照组由从社区招募的74名健康个体组成。他们在年龄和性别上与研究组相匹配。
躁狂症患者组的NLR值为2.2±1.4，对照组为1.6±0.5。躁狂症患者组的NLR值显著更高（p = 0.004），且MPV值显著低于对照组（10.0±1.2对10.9±2.3，p = 0.027）。
NLR升高和MPV水平降低可能反映躁狂症患者存在炎症，且炎症可能在急性躁狂症复杂的病理生理过程中起作用。
