评估炎症的简单标志物和炎症及全身免疫指数在精神分裂症、双相情感障碍患者及健康对照者中的差异。
Evaluation of Simple Markers of Inflammation and Systemic Immune Inflammation Index in Schizophrenia, Bipolar Disorder Patients and Healthy Controls.
出版信息
Turk Psikiyatri Derg. 2023 Spring;34(1):11-15. doi: 10.5080/u26248.
OBJECTIVE
Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), mean platelet volume (MPV), and systemic immune inflammation index (SII) are recently used as indicators of inflammation. NLR, PLR, MLR, and MPV have been evaluated in many studies in patients with schizophrenia and bipolar disorder. However, there are no studies investigating SII. This study aims to evaluate NLR, PLR, MLR, MPV and SII values and complete blood count elements in patients hospitalized with diagnoses of the schizophrenia with psychotic episode and bipolar disorder with manic episode by comparing them with the control group.
METHOD
A total of 149 patients who were hospitalized with the diagnoses of the schizophrenia with psychotic episode and bipolar disorder with manic episode and who met the inclusion criteria were included in our study where the control group was composed of 66 healthy individuals. White blood cell (WBC), neutrophil, lymphocyte, platelet, and monocyte counts were obtained retrospectively from complete blood counts at the time of admission, based on which NLR, PLR, MLR, and SII were calculated.
RESULTS
In this study, higher NLR, PLR, and SII values and lower MPV and lymphocyte counts were observed in schizophrenia patients compared to the control group. NLR, PLR, and SII values and neutrophil counts were higher in patients with bipolar disorder compared to the control group. Lower MPV values were found in patients with schizophrenia compared to patients with bipolar disorder.
CONCLUSION
Simple inflammatory and SII values in our study indicate the presence of low-grade systemic inflammation in schizophrenia and bipolar disorder.
目的
中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）、平均血小板体积（MPV）和全身免疫炎症指数（SII）最近被用作炎症指标。NLR、PLR、MLR 和 MPV 已在许多精神分裂症和双相情感障碍患者的研究中进行了评估。然而，目前尚无研究调查 SII。本研究旨在通过与对照组比较，评估住院诊断为精神分裂症伴有精神病发作和双相情感障碍伴有躁狂发作的患者的 NLR、PLR、MLR、MPV 和 SII 值以及全血细胞计数元素。
方法
共纳入 149 例符合纳入标准的住院诊断为精神分裂症伴有精神病发作和双相情感障碍伴有躁狂发作的患者，对照组由 66 例健康个体组成。根据入院时的全血细胞计数，回顾性获得白细胞（WBC）、中性粒细胞、淋巴细胞、血小板和单核细胞计数，并计算 NLR、PLR、MLR 和 SII。
结果
与对照组相比，精神分裂症患者的 NLR、PLR 和 SII 值较高，MPV 和淋巴细胞计数较低。与对照组相比，双相情感障碍患者的 NLR、PLR 和 SII 值以及中性粒细胞计数较高。与双相情感障碍患者相比，精神分裂症患者的 MPV 值较低。
结论
本研究中的简单炎症和 SII 值表明精神分裂症和双相情感障碍存在低度全身炎症。
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