衰老的开始受到嗜热栖粪壳菌中一个不连续线粒体基因的DNA重排的影响。
The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina.
作者信息
Kück U, Osiewacz H D, Schmidt U, Kappelhoff B, Schulte E, Stahl U, Esser K
机构信息
Lehrstuhl für Allgemeine Botanik, Ruhr-Universität Bochum, Federal Republic of Germany.
出版信息
Curr Genet. 1985;9(5):373-82. doi: 10.1007/BF00421608.
Mapping and transcription studies have revealed that in Podospora anserina the causative agent of senescence, a mitochondrial plasmid (plDNA), is identical with intron 1 of the discontinuous gene for cytochrome-c-oxidase subunit 1 (COI), which is 2 kpb from the discontinuous gene for cytochrome b (Cytb). A mitochondrial mutant (ex1) devoid of the COI, but not of the Cytb gene provides longevity. A molecular model for the onset of senescence is presented.
图谱绘制和转录研究表明，在衰老的致病因子——嗜鸟粪盘菌中，一种线粒体质粒（plDNA）与细胞色素c氧化酶亚基1（COI）的间断基因的内含子1相同，该内含子距细胞色素b（Cytb）的间断基因2千碱基对。一种缺乏COI基因但不缺乏Cytb基因的线粒体突变体（ex1）具有较长寿命。本文提出了衰老起始的分子模型。
Zotero 插件