一对患有乳腺癌、携带BRCA2基因突变且双侧有多余乳头的兄妹。
A brother and sister with breast cancer, BRCA2 mutations and bilateral supernumerary nipples.
作者信息
McKay Michael, Coad Ryan
机构信息
University of Sydney, Department of Medicine, Camperdown, 2050 NSW, Australia.
North Coast Cancer Institute, Lismore, 2480 NSW, Australia.
出版信息
Ann Transl Med. 2017 Mar;5(5):106. doi: 10.21037/atm.2017.03.02.
We describe a 54-year-old man with breast cancer and a BRCA2 mutation who was also found to have bilateral supernumerary nipples. His sister, also with a BRCA2 mutation, was diagnosed with breast cancer in her late forties; she also had bilateral supernumerary nipples. We address the significance of breast cancer arising in breast tissue underlying supernumerary nipples; the known association between supernumerary nipples and genitourinary malignancies/malformations and the possible link between BRCA2 and supernumerary nipple development. We believe that this is the first described case of the latter. We then outline an approach to further management for supernumerary nipple cases.
我们描述了一名54岁患有乳腺癌且携带BRCA2突变的男性，他还被发现双侧有多余乳头。他的姐姐也携带BRCA2突变，在近五十岁时被诊断出患有乳腺癌；她同样有双侧多余乳头。我们探讨了在多余乳头下方乳腺组织中发生乳腺癌的意义；多余乳头与泌尿生殖系统恶性肿瘤/畸形之间已知的关联以及BRCA2与多余乳头发育之间可能的联系。我们认为这是首例关于后者的描述病例。然后我们概述了针对多余乳头病例的进一步管理方法。
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