Fiorini G F, Sinico R A, Winearls C, Custode P, De Giuli-Morghen C, D'Amico G
Haematology Department, San Carlo General Hospital, Milan, Italy.
Clin Immunol Immunopathol. 1988 Jun;47(3):262-9. doi: 10.1016/s0090-1229(88)80004-7.
The pattern of response to Epstein-Barr virus (EBV) has been investigated in 17 patients with essential mixed cryoglobulinemia (EMC) and in 17 control subjects. All subjects in both groups had IgG to the viral capsid antigen at comparable titers. In the absence of signs of recent infection, 13 patients had IgM to viral capsid antigen and 5 had also IgA, while all the controls were negative. EBV genome was present in bone marrow lymphocytes obtained from 4 patients with type II EMC, but not in those of one patient with type III disease; the latter patient's lymphocytes also failed to produce detectable levels of rheumatoid factor in culture, while the other four patients' lymphocytes released high amounts in culture supernatants. These data support the evidence of an association between type II EMC and persistent EBV infection.
对17例原发性混合性冷球蛋白血症（EMC）患者和17例对照者的爱泼斯坦-巴尔病毒（EBV）反应模式进行了研究。两组所有受试者的病毒衣壳抗原IgG滴度相当。在无近期感染迹象的情况下，13例患者存在病毒衣壳抗原IgM，5例患者还存在IgA，而所有对照者均为阴性。从4例II型EMC患者获得的骨髓淋巴细胞中存在EBV基因组，但1例III型疾病患者的骨髓淋巴细胞中不存在；后1例患者的淋巴细胞在培养中也未能产生可检测水平的类风湿因子，而其他4例患者的淋巴细胞在培养上清液中释放大量类风湿因子。这些数据支持了II型EMC与持续性EBV感染之间存在关联的证据。
