路易体痴呆患者临床症状与纹状体多巴胺转运体摄取之间的相关性。
Correlation between clinical symptoms and striatal DAT uptake in patients with DLB.
作者信息
Shimizu Soichiro, Hirose Disuke, Namioka Nayuta, Kanetaka Hidekazu, Hirao Kentaro, Hatanaka Hirokuni, Takenoshita Naoto, Kaneko Yoshitsugu, Ogawa Yusuke, Umahara Takahiko, Sakurai Hirofumi, Hanyu Haruo
机构信息
Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
出版信息
Ann Nucl Med. 2017 Jun;31(5):390-398. doi: 10.1007/s12149-017-1166-3. Epub 2017 Mar 30.
OBJECTIVE
It is widely known that there is low striatal I-FP-CIT dopamine transporter-single photon emission tomography (DAT-SPECT) uptake in patients with dementia with Lewy bodies (DLB). We assessed the correlation between symptom and regional low DAT uptake in the striatum.
METHODS
Patients with Alzheimer's disease (AD) (n = 95) and patients with DLB (n = 133) who underwent DAT-SPECT were enrolled. We examined the correlation between symptoms [cognitive function decline, fluctuations, visual hallucinations, parkinsonism, and REM sleep behavior disorder (RBD)] and regional striatal DAT uptake in the patients with DLB.
RESULTS
When comparing the DLB patients with or without fluctuations, visual hallucinations, or RBD, there were no significant differences in DAT uptake in any regions of the striatum. DLB patients with parkinsonism had significantly lower DAT uptake in entire striatum, entire putamen, and anterior putamen compared to DLB patients without parkinsonism. Moreover, there was weak but significant correlation between severity of parkinsonism and DAT uptake in entire regions of the striatum in patients with DLB. There was no significant correlation between cognitive function and DAT uptake in any regions of the striatum in patients with DLB.
CONCLUSIONS
In patients with DLB, only parkinsonism is associated with a reduction in striatal DAT uptake.
目的
众所周知，路易体痴呆（DLB）患者纹状体中碘-氟哌啶醇-对碘苄胍多巴胺转运体-单光子发射计算机断层扫描（DAT-SPECT）摄取量较低。我们评估了症状与纹状体区域DAT摄取量降低之间的相关性。
方法
纳入接受DAT-SPECT检查的阿尔茨海默病（AD）患者（n = 95）和DLB患者（n = 133）。我们研究了DLB患者的症状[认知功能下降、症状波动、视幻觉、帕金森综合征和快速眼动睡眠行为障碍（RBD）]与纹状体区域DAT摄取量之间的相关性。
结果
比较有或无症状波动、视幻觉或RBD的DLB患者时，纹状体任何区域的DAT摄取量均无显著差异。与无帕金森综合征的DLB患者相比，有帕金森综合征的DLB患者在整个纹状体、整个壳核和壳核前部的DAT摄取量显著降低。此外，DLB患者帕金森综合征的严重程度与整个纹状体区域的DAT摄取量之间存在弱但显著的相关性。DLB患者的认知功能与纹状体任何区域的DAT摄取量之间均无显著相关性。
结论
在DLB患者中，只有帕金森综合征与纹状体DAT摄取量降低有关。
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