用于区分路易体痴呆（DLB）与阿尔茨海默病（AD）的多巴胺转运体单光子发射计算机断层扫描（DAT-SPECT）半定量分析的诊断效用比较
Comparison of diagnostic utility of semi-quantitative analysis for DAT-SPECT for distinguishing DLB from AD.
作者信息
Shimizu Soichiro, Namioka Nayuta, Hirose Daisuke, Kanetaka Hidekazu, Hirao Kentaro, Hatanaka Hirokuni, Takenoshita Naoto, Kaneko Yoshitsugu, Ogawa Yusuke, Tsugawa Akito, Umahara Takahiko, Sakurai Hirofumi, Hanyu Haruo
机构信息
Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
出版信息
J Neurol Sci. 2017 Jun 15;377:50-54. doi: 10.1016/j.jns.2017.03.040. Epub 2017 Mar 27.
PURPOSE
It is widely known that there is low striatal I-FP-CIT dopamine transporter single photon emission computed tomography (DAT-SPECT) uptake in patients with dementia with Lewy bodies (DLB). However, a consistent quantitative evaluation method for DAT-SPECT has not yet been established. There are two semi-quantitative software packages for DAT-SPECT available in Japan, namely, DaTView and DaTQUANT. The aim of this study was to identify which of these is superior for distinguishing DLB from AD. Moreover, we aimed to identify which region of the striatum is more suitable for distinguishing DLB from AD.
METHODS
Patients with Alzheimer's disease (AD) (n=95) and patients with DLB (n=133) who underwent DAT-SPECT were enrolled. DaTView and DaTQUANT were used as semi-quantitative analysis tools for DAT-SPECT.
RESULTS
There were significant correlations in DAT uptake between DaTView and entire regions by DaTQUANT. There was no significant difference in diagnostic accuracy between DaTView and DaTQUANT except in the posterior putamen by DaTQUANT.
CONCLUSIONS
For distinguishing DLB from AD, both of DaTView and DaTQUANT software are useful. Moreover, assessing the DAT uptake in entire striatum by DaTView might be sufficient for distinguishing DLB from AD.
目的
众所周知，路易体痴呆（DLB）患者纹状体中碘氟培他美（I-FP-CIT）多巴胺转运体单光子发射计算机断层扫描（DAT-SPECT）摄取量较低。然而，尚未建立一种一致的DAT-SPECT定量评估方法。日本有两种用于DAT-SPECT的半定量软件包，即DaTView和DaTQUANT。本研究的目的是确定其中哪一种在区分DLB和AD方面更具优势。此外，我们旨在确定纹状体的哪个区域更适合区分DLB和AD。
方法
纳入接受DAT-SPECT检查的阿尔茨海默病（AD）患者（n = 95）和DLB患者（n = 133）。使用DaTView和DaTQUANT作为DAT-SPECT的半定量分析工具。
结果
DaTView与DaTQUANT对整个区域的DAT摄取量之间存在显著相关性。除了DaTQUANT对壳核后部的诊断准确性外，DaTView和DaTQUANT之间的诊断准确性没有显著差异。
结论
对于区分DLB和AD，DaTView和DaTQUANT软件都很有用。此外，通过DaTView评估整个纹状体的DAT摄取量可能足以区分DLB和AD。
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