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癫痫:有希望吗?

Epilepsy: Is there hope?

作者信息

Guerreiro Carlos A M

机构信息

Department of Neurology, Campinas University, Campinas, Brazil.

出版信息

Indian J Med Res. 2016 Nov;144(5):657-660. doi: 10.4103/ijmr.IJMR_1051_16.

Abstract

Epilepsy is a highly prevalent chronic neurologic disorder and leads to social, behavioural, health and economic consequences. 'Treatment gap' varies from 10 per cent in developed countries to 75 per cent in low-income countries. Stigma and discrimination related to epilepsy are prevalent worldwide. Electroencephalography (EEG) is considered the most important tool for evaluating the patient with epilepsy. Video-EEG monitoring is an important tool for confirming the seizure type and estimating the epileptogenic zone in the brain. Neuroimaging evaluation is important to determine the aetiology of the epilepsies. Genetic testing has increased the probability of identifying the causes of some types of epilepsies. Epilepsy can be treated in an affordable way with low-cost medications. Refractory epilepsies occur in approximately one-third of recently diagnosed patients with epilepsy. For this group of patients, there are options of surgical treatment, diets and neurostimulation to improve seizure control and quality of life. In poorly organized societies, there is a lack of prioritization of epilepsy in national health policies, limited resources for trained personnel and a shortage of basic antiepileptic medications. There is evidence of improvement in the understanding of epilepsy and a clear progress in the management of epileptic seizures in recent times.

摘要

癫痫是一种高度流行的慢性神经系统疾病,会导致社会、行为、健康和经济方面的后果。“治疗缺口”在发达国家为10%,在低收入国家则高达75%。与癫痫相关的耻辱感和歧视在全球普遍存在。脑电图(EEG)被认为是评估癫痫患者最重要的工具。视频脑电图监测是确认癫痫发作类型和估计大脑中癫痫病灶区的重要工具。神经影像学评估对于确定癫痫的病因很重要。基因检测提高了识别某些类型癫痫病因的可能性。癫痫可以用低成本药物以负担得起的方式进行治疗。难治性癫痫约发生在最近诊断出的三分之一癫痫患者中。对于这组患者,有手术治疗、饮食和神经刺激等选择,以改善癫痫发作控制和生活质量。在组织不善的社会中,国家卫生政策对癫痫缺乏优先考虑,训练有素的人员资源有限,基本抗癫痫药物短缺。有证据表明,近年来人们对癫痫的认识有所提高,癫痫发作的管理也有了明显进展。

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