沙特人群中电压门控钾通道多态性与癫痫风险及预后的关联：一项病例对照研究
Association of Voltage-Gated Potassium Channel Polymorphisms with the Risk and Prognosis of Epilepsy in the Saudi Population: A Case-Control Study.
作者信息
Alghamdi Mansour A, Al-Eitan Laith N, Otaif Mansour Y, Rababa'h Doaa M, Alasmar Maryam K, Al-Garni Abdulaziz M, Saleh Rayyh A M, Abdel Ghaffar Nawal F
机构信息
Department of Anatomy, College of Medicine, King Khalid University, Abha 62529, Saudi Arabia.
Genomics and Personalized Medicine Unit, The Center for Medical and Health Research, King Khalid University, Abha 62529, Saudi Arabia.
出版信息
Medicina (Kaunas). 2025 Feb 25;61(3):396. doi: 10.3390/medicina61030396.
: Epilepsy, known as an unprovoked seizure, arises from the human brain. Genetics plays a fundamental role in the development and progression of the disorder. This study aimed to investigate the influence of voltage-gated K channels on the risk of epilepsy. : Several genetic variants were examined using PCR sequencing. This case-control study was conducted on 296 individuals who were diagnosed with epilepsy, in addition to 293 healthy participants. : This study revealed that within , both rs3755631 and rs4679773 are correlated with epilepsy, and the -values = 0.04 for both allelic associations. In addition, regarding the gene, we found that rs2820585, rs946420, rs1186679, rs61822012, and rs1186685 were significantly correlated with epilepsy risk (-values = 0.034, 0.045, 0.021, 0.048, and 0.018), respectively. : From the current study, we conclude that voltage-gated potassium channels can impact epilepsy risk and can also interfere with the prognosis of epilepsy.
癫痫，即无端发作，源于人类大脑。遗传学在该疾病的发生和发展中起着根本性作用。本研究旨在调查电压门控钾通道对癫痫风险的影响。：使用聚合酶链反应测序检测了多个基因变体。这项病例对照研究对296名被诊断患有癫痫的个体以及293名健康参与者进行。：本研究表明，在……范围内，rs3755631和rs4679773均与癫痫相关，且两个等位基因关联的P值均为0.04。此外，关于……基因，我们发现rs2820585、rs946420、rs1186679、rs61822012和rs1186685分别与癫痫风险显著相关（P值分别为0.034、0.045、0.021、0.048和0.018）。：从当前研究中，我们得出结论，电压门控钾通道可影响癫痫风险，也可干扰癫痫的预后。
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