Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
Org Lett. 2017 Apr 21;19(8):1994-1997. doi: 10.1021/acs.orglett.7b00533. Epub 2017 Mar 31.
A novel, simple, and practical visible-light-mediated intramolecular α-C(sp)-H imination of tertiary aliphatic amines containing β-O-aryl oximes leading to N-heterocycles has been developed. The reaction was performed well at rt with tolerance of some functional groups. Importantly, the selective C-H functionalization did not require added catalyst, oxidant, additive, acid, and base; visible light was the sole requirement.
一种新型、简单、实用的可见光促进的含β-O-芳基肟的叔脂肪族伯胺的分子内α-C(sp)-H 亚胺化反应，生成 N-杂环化合物。该反应在室温下进行得很好，对一些官能团具有容忍性。重要的是，选择性的 C-H 官能化不需要添加催化剂、氧化剂、添加剂、酸和碱；可见光就是唯一的要求。
