Modulation of atrial natriuretic peptide-induced cGMP accumulation by [Arg8]vasopressin in the cultured renal epithelial cell line, LLC-PK1.
作者信息
Neuser D, Stasch J P, Morich F J
机构信息
Bayer AG, Analytical Therapy Research, Department of Pharmacology, Wuppertal, F.R.G.
出版信息
Eur J Pharmacol. 1988 Feb 9;146(2-3):341-4. doi: 10.1016/0014-2999(88)90313-5.
PMID:2836211
Abstract
Atrial natriuretic peptide (ANP) III stimulated the formation of intracellular cGMP in renal epithelial cells (LLC-PK1) dose dependently. Incubation of LLC-PK1 cells with [Arg8]vasopressin resulted in an increase in intracellular cAMP levels. The stimulatory effect of ANP III on the cyclic cGMP system was inhibited by coincubation with [Arg8]vasopressin in a dose-dependent manner.
摘要
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