Schinke Claudia, Martins Thamires, Queiroz Sonia C N, Melo Itamar S, Reyes Felix G R
Department of Food Science, School of Food Engineering, University of Campinas , Campinas-SP, CEP 13083-862, Brazil.
Brazilian Agricultural Research Corporation , Rodovia SP-340 km 127.5, Jaguariúna-SP, CEP 13820-000, Brazil.
J Nat Prod. 2017 Apr 28;80(4):1215-1228. doi: 10.1021/acs.jnatprod.6b00235. Epub 2017 Mar 31.
This review summarizes the reports on antibacterial compounds that have been obtained from marine-derived bacteria during the period 2010-2015. Over 50 active compounds were isolated during this period, most of which (69%) were obtained from Actinobacteria. Several compounds were already known, such as etamycin A (11) and nosiheptide (65), and new experiments with them showed some previously undetected antibacterial activities, highlighting the fact that known natural products may be an important source of new antibacterial leads. New broad-spectrum antibacterial compounds were reported with activity against antibiotic resistant Gram-positive and Gram-negative bacteria. Anthracimycin (33), kocurin (66), gageotetrins A-C (72-74), and gageomacrolactins 1-3 (86-88) are examples of compounds that display promising properties and could be leads to new antibiotics. A number of microbes produced mixtures of metabolites sharing similar chemical scaffolds, and structure-activity relationships are discussed.
本综述总结了2010年至2015年期间从海洋来源细菌中获得的抗菌化合物的相关报道。在此期间分离出了50多种活性化合物，其中大部分（69%）来自放线菌。一些化合物是已知的，如埃他霉素A（11）和诺西肽（65），对它们进行的新实验显示出一些以前未检测到的抗菌活性，这突出了已知天然产物可能是新抗菌先导物的重要来源这一事实。有报道称发现了新的广谱抗菌化合物，它们对耐抗生素的革兰氏阳性菌和革兰氏阴性菌具有活性。炭疽霉素（33）、科库林（66）、盖奥替菌素A - C（72 - 74）以及盖奥大环内酯1 - 3（86 - 88）都是具有良好特性、有望成为新型抗生素先导物的化合物实例。许多微生物产生了具有相似化学骨架的代谢物混合物，并对其构效关系进行了讨论。
