Tian W, Chen L, Zhang L, Wang B, Li X B, Fan K R, Ai C H, Xia X, Li S D, Li Y
Department of Cadre Health, First People's Hospital of Yunnan Province, Kunming, Yunnan, China.
Department of Biomedical Science, School of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
Genet Mol Res. 2017 Mar 30;16(1):gmr-16-01-gmr.16019463. doi: 10.4238/gmr16019463.
Type 2 diabetes mellitus (T2-DM) is a chronic metabolic disorder characterized by high blood glucose levels. T2-DM patients suffer from many complications, such as diabetic fatty liver and diabetic nephropathy. The liver, the pivotal organ involved in both glucose and lipid metabolism, is primarily damaged in T2-DM patients, especially in those with high levels of blood lipid. In this study, the hepatoprotective activity of ginsenoside Rg1 was investigated in a T2-DM rat model. The results revealed a potent hepatoprotective effect of ginsenoside Rg1. This effect was primarily mediated by the antiapoptotic effect, inhibition of JNK activity, and suppression of inflammation after ginsenoside Rg1 treatment. Ginsenoside Rg1 also lowered the blood glucose level and insulin resistance index in T2-DM rats. Moreover, the blood lipid profile (total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels) and liver function (aspartate transaminase and alanine transaminase levels) improved after ginsenoside Rg1 treatment. The aforementioned hepatoprotective effects of ginsenoside Rg1 in the T2-DM rat model suggests its clinical potential as an adjuvant drug for T2-DM therapy, especially for T2-DM patients with fatty liver disease.
2型糖尿病（T2-DM）是一种以血糖水平升高为特征的慢性代谢紊乱疾病。T2-DM患者会出现许多并发症，如糖尿病性脂肪肝和糖尿病肾病。肝脏是参与葡萄糖和脂质代谢的关键器官，在T2-DM患者中主要受到损害，尤其是在血脂水平高的患者中。在本研究中，在T2-DM大鼠模型中研究了人参皂苷Rg1的肝脏保护活性。结果显示人参皂苷Rg1具有强大的肝脏保护作用。这种作用主要是通过人参皂苷Rg1治疗后的抗凋亡作用、JNK活性的抑制和炎症的抑制介导的。人参皂苷Rg1还降低了T2-DM大鼠的血糖水平和胰岛素抵抗指数。此外，人参皂苷Rg1治疗后血脂谱（总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平）和肝功能（天冬氨酸转氨酶和丙氨酸转氨酶水平）得到改善。人参皂苷Rg1在T2-DM大鼠模型中的上述肝脏保护作用表明其作为T2-DM治疗辅助药物的临床潜力，特别是对于患有脂肪肝疾病的T2-DM患者。
