a Coastal Zones Research Institute Inc. (CZRI), Shippagan, NB E8S 1J2, Canada.
b Natural Health Products Program, Aquatic and Crop Resource Development, National Research Council of Canada, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada.
Appl Physiol Nutr Metab. 2017 Aug;42(8):841-849. doi: 10.1139/apnm-2016-0644. Epub 2017 Mar 31.
Diet-induced obesity, insulin resistance, impaired glucose tolerance, chronic inflammation, and oxidative stress represent the main features of type 2 diabetes mellitus. The present study was conducted to examine the efficacy and mechanisms of shrimp oil on glucose homeostasis in obese rats. Male CD rats fed a high-fat diet (52 kcal% fat) and 20% fructose drinking water were divided into 4 groups and treated with the dietary replacement of 0%, 10%, 15%, or 20% of lard with shrimp oil for 10 weeks. Age-matched rats fed a low-fat diet (10 kcal% fat) were used as the normal control. Rats on the high-fat diet showed impaired (p < 0.05) glucose tolerance and insulin resistance compared with rats fed the low-fat diet. Shrimp oil improved (p < 0.05) oral glucose tolerance, insulin response, and homeostatic model assessment-estimated insulin resistance index; decreased serum insulin, leptin, hemoglobin A1c, and free fatty acids; and increased adiponectin. Shrimp oil also increased (p < 0.05) antioxidant capacity and reduced oxidative stress and chronic inflammation. The results demonstrated that shrimp oil dose-dependently improved glycemic control in obese rats through multiple mechanisms.
饮食诱导的肥胖、胰岛素抵抗、葡萄糖耐量受损、慢性炎症和氧化应激是 2 型糖尿病的主要特征。本研究旨在探讨虾油对肥胖大鼠糖稳态的疗效和作用机制。雄性 CD 大鼠给予高脂肪饮食（52%脂肪热量）和 20%果糖饮用水，分为 4 组，用虾油替代 0%、10%、15%或 20%的猪油进行 10 周的饮食替代治疗。用喂食低脂肪饮食（10%脂肪热量）的同龄大鼠作为正常对照组。与喂食低脂肪饮食的大鼠相比，高脂肪饮食的大鼠表现出葡萄糖耐量受损（p<0.05）和胰岛素抵抗。虾油改善（p<0.05）口服葡萄糖耐量、胰岛素反应和稳态模型评估估计的胰岛素抵抗指数；降低血清胰岛素、瘦素、糖化血红蛋白和游离脂肪酸；并增加脂联素。虾油还增加（p<0.05）抗氧化能力，减少氧化应激和慢性炎症。结果表明，虾油通过多种机制剂量依赖性地改善肥胖大鼠的血糖控制。
