Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
Department of Biosciences, Himachal Pradesh University, Shimla 171005, India.
Carbohydr Polym. 2017 Jun 1;165:294-303. doi: 10.1016/j.carbpol.2017.02.039. Epub 2017 Feb 20.
Keeping in view the importance of polysaccharide gums for wound care, in the present article, an attempt has been made to explore antioxidant nature of gum acacia in designing hydrogel wound dressing to improve its wound healing potential. These polymers were prepared by using acacia gum-polyvinylpyrollidone/carbopol and were characterized by C NMR, FTIR, SEM, AFM, cryo-SEM, XRD, TGA, DSC and elemental analysis techniques. Some important biomaterial properties of wound dressings such as wound fluid absorption, haemo-compatibility, bioactive assessment, gaseous/water/microbial permeability, mechanical properties, bio-adhesion, drug release, and histology of wound healing were also determined. Hydrogel wound dressings were found non-haemolytic, antioxidant and mucoadhesive in nature. Release of drug occurred through non-Fickian diffusion mechanism and release profile best fitted in Higuchi model.
鉴于多糖胶在伤口护理中的重要性，本文试图探索金合欢胶在设计水凝胶伤口敷料中的抗氧化特性，以提高其伤口愈合潜力。这些聚合物是通过使用金合欢胶-聚乙烯吡咯烷酮/卡波姆制备的，并通过 C NMR、FTIR、SEM、AFM、冷冻 SEM、XRD、TGA、DSC 和元素分析技术进行了表征。伤口敷料的一些重要生物材料特性，如伤口流体吸收、血液相容性、生物活性评估、气体/水/微生物渗透性、机械性能、生物粘附性、药物释放和伤口愈合的组织学也得到了确定。水凝胶伤口敷料被发现具有非溶血、抗氧化和天然粘膜粘附性。药物释放是通过非菲克扩散机制发生的，释放曲线最符合 Higuchi 模型。
