Sudenga Staci L, Nyitray Alan G, Torres B Nelson, Silva Roberto, Villa Luisa, Lazcano-Ponce Eduardo, Abrahamsen Martha, Baggio Maria Luiza, Salmeron Jorge, Quiterio Manuel, Giuliano Anna R
Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA; Division of Epidemiology, Vanderbilt University, Nashville, TN, USA.
Center for Infectious Disease, The University of Texas School of Public Health at Houston, TX, USA.
J Infect. 2017 Jul;75(1):35-47. doi: 10.1016/j.jinf.2017.03.010. Epub 2017 Mar 28.
Globally, anal cancer incidence is rare, but is increasing in some world regions. Our objective was to assess differences in anal HPV natural history in three countries.
Men aged 18-70 years were recruited from the US (n = 634), Mexico (n = 665), and Brazil (n = 731). Anal specimens were collected every six-months. HPV genotyping was assessed by Linear Array. Anal HPV prevalence was compared using the Fisher's exact test. HPV infection incidence rates (IR) and 95% confidence intervals (CI) were calculated.
Any anal HPV prevalence was highest among men from Brazil (24%) compared to Mexico (15%) and the US (15%). When stratified by sexual history, the prevalence of any HPV among MSM/MSMW was 43%, 37%, and 45% and 9%, 12%, and 10% for MSW from Brazil, Mexico, and US, respectively. Any HPV incidence was significantly higher among men from Brazil compared to US men (IRR = 2.4, 95% CI = 1.7-3.4) and comparable between men from Mexico and the US (IRR = 1.2, 95% CI = 0.8-1.8).
Men in Brazil and Mexico often have similar, if not higher incidence of anal HPV compared to men from the U.S., and may benefit from gender neutral HPV vaccine policies.
在全球范围内，肛门癌的发病率很低，但在世界某些地区呈上升趋势。我们的目的是评估三个国家肛门人乳头瘤病毒（HPV）自然史的差异。
招募年龄在18至70岁之间的男性，来自美国（n = 634）、墨西哥（n = 665）和巴西（n = 731）。每六个月收集一次肛门标本。采用线性阵列法进行HPV基因分型评估。使用Fisher精确检验比较肛门HPV感染率。计算HPV感染发病率（IR）和95%置信区间（CI）。
与墨西哥（15%）和美国（15%）相比，巴西男性的任何肛门HPV感染率最高（24%）。按性病史分层时，巴西、墨西哥和美国男男性行为者/男男性行为女性化者中任何HPV的感染率分别为43%、37%和45%，而三国异性恋男性中分别为9%、12%和10%。与美国男性相比，巴西男性的任何HPV发病率显著更高（发病率比值比[IRR]=2.4，95%CI=1.7-3.4），而墨西哥男性和美国男性的发病率相当（IRR=1.2，95%CI=0.8-1.8）。
与美国男性相比，巴西和墨西哥男性的肛门HPV发病率即使不更高也往往相似，可能受益于不分性别的HPV疫苗政策。
