鞘内注射胰岛素样生长因子1可促进幼龄和老龄大鼠的髓鞘修复，而胰岛素则无此作用。

Intrathecal insulin-like growth factor 1 but not insulin enhances myelin repair in young and aged rats.

作者信息

Hlavica Martin, Delparente Aro, Good Andrin, Good Nicolas, Plattner Patricia S, Seyedsadr Maryam S, Schwab Martin E, Figlewicz Dianne P, Ineichen Benjamin V

机构信息

Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland; Cantonal Hospital St.Gallen, Department of Neurosurgery, Switzerland.

Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland.

出版信息

Neurosci Lett. 2017 May 1;648:41-46. doi: 10.1016/j.neulet.2017.03.047. Epub 2017 Mar 29.

DOI:10.1016/j.neulet.2017.03.047

PMID:28363754

Abstract

One main pathological hallmark of multiple sclerosis (MS) is demyelination. Novel therapies which enhance myelin repair are urgently needed. Insulin and insulin-like growth factor 1 (IGF-1) have strong functional relationships. Here, we addressed the potential capacity of IGF-1 and insulin to enhance remyelination in an animal demyelination model in vivo. We found that chronic intrathecal infusion of IGF-1 enhanced remyelination after lysolecithin-induced demyelination in the spinal cord of young and aged rats. Aged rats showed a weaker innate remyelination capacity and are therefore a good model for progressive MS which is defined by chronic demyelination. In contrast to IGF-1, Insulin had no effect on remyelination in either age group. Our findings highlight the potential use of IGF-1 as remyelinating therapy for MS, particularly the progressive stage in which chronic demyelination is the hallmark.

摘要

多发性硬化症（MS）的一个主要病理特征是脱髓鞘。迫切需要能够促进髓鞘修复的新疗法。胰岛素和胰岛素样生长因子1（IGF-1）具有密切的功能关系。在此，我们探讨了IGF-1和胰岛素在体内动物脱髓鞘模型中促进髓鞘再生的潜在能力。我们发现，慢性鞘内注射IGF-1可增强卵磷脂诱导的年轻和老年大鼠脊髓脱髓鞘后的髓鞘再生。老年大鼠的固有髓鞘再生能力较弱，因此是由慢性脱髓鞘定义的进展性MS的良好模型。与IGF-1相反，胰岛素对任何年龄组的髓鞘再生均无影响。我们的研究结果突出了IGF-1作为MS髓鞘再生治疗方法的潜在用途，特别是在以慢性脱髓鞘为特征的进展期。