Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Neurosci Bull. 2023 Mar;39(3):466-478. doi: 10.1007/s12264-023-01034-9. Epub 2023 Feb 28.
Multiple sclerosis (MS) is regarded as a chronic inflammatory disease that leads to demyelination and eventually to neurodegeneration. Activation of innate immune cells and other inflammatory cells in the brain and spinal cord of people with MS has been well described. However, with the innovation of technology in glial cell research, we have a deep understanding of the mechanisms of glial cells connecting inflammation and neurodegeneration in MS. In this review, we focus on the role of glial cells, including microglia, astrocytes, and oligodendrocytes, in the pathogenesis of MS. We mainly focus on the connection between glial cells and immune cells in the process of axonal damage and demyelinating neuron loss.
多发性硬化症（MS）被认为是一种慢性炎症性疾病，可导致脱髓鞘并最终导致神经退行性变。MS 患者大脑和脊髓中固有免疫细胞和其他炎症细胞的激活已得到充分描述。然而，随着胶质细胞研究技术的创新，我们对胶质细胞在 MS 中连接炎症和神经退行性变的机制有了更深入的了解。在这篇综述中，我们重点关注胶质细胞（包括小胶质细胞、星形胶质细胞和少突胶质细胞）在 MS 发病机制中的作用。我们主要关注胶质细胞与免疫细胞在轴突损伤和脱髓鞘神经元丢失过程中的联系。
