西班牙女性的睡眠模式、睡眠障碍与乳腺X线密度：DDM-西班牙/Var-DDM研究
Sleep patterns, sleep disorders and mammographic density in spanish women: The DDM-Spain/Var-DDM study.
作者信息
Pedraza-Flechas Ana María, Lope Virginia, Moreo Pilar, Ascunce Nieves, Miranda-García Josefa, Vidal Carmen, Sánchez-Contador Carmen, Santamariña Carmen, Pedraz-Pingarrón Carmen, Llobet Rafael, Aragonés Nuria, Salas-Trejo Dolores, Pollán Marina, Pérez-Gómez Beatriz
机构信息
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain.
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), CIBERESP, Spain.
出版信息
Maturitas. 2017 May;99:105-108. doi: 10.1016/j.maturitas.2017.02.015. Epub 2017 Feb 28.
We explored the relationship between sleep patterns and sleep disorders and mammographic density (MD), a marker of breast cancer risk. Participants in the DDM-Spain/var-DDM study, which included 2878 middle-aged Spanish women, were interviewed via telephone and asked questions on sleep characteristics. Two radiologists assessed MD in their left craneo-caudal mammogram, assisted by a validated semiautomatic-computer tool (DM-scan). We used log-transformed percentage MD as the dependent variable and fitted mixed linear regression models, including known confounding variables. Our results showed that neither sleeping patterns nor sleep disorders were associated with MD. However, women with frequent changes in their bedtime due to anxiety or depression had higher MD (e:1.53;95%CI:1.04-2.26).
我们探究了睡眠模式、睡眠障碍与乳房X线密度（MD，一种乳腺癌风险标志物）之间的关系。DDM-西班牙/可变DDM研究中的参与者包括2878名西班牙中年女性，通过电话对她们进行了访谈，并询问了睡眠特征方面的问题。两名放射科医生在一款经过验证的半自动计算机工具（DM-扫描）辅助下，对她们左侧头尾位乳房X线照片的MD进行了评估。我们将对数转换后的MD百分比作为因变量，并拟合了包含已知混杂变量的混合线性回归模型。我们的结果显示，睡眠模式和睡眠障碍均与MD无关。然而，因焦虑或抑郁导致就寝时间频繁变化的女性MD较高（比值比：1.53；95%置信区间：1.04-2.26）。
Zotero 插件