Durgan David J
Department of Anesthesiology, Baylor College of Medicine, One Baylor Plaza, Room 434D, Houston, TX, 77030, USA.
Curr Hypertens Rep. 2017 Apr;19(4):35. doi: 10.1007/s11906-017-0732-3.
Obstructive sleep apnea (OSA) is a significant risk factor for systemic hypertension and other cardiovascular diseases. While this relationship has been firmly established, a detailed understanding of how OSA leads to hypertension is lacking. This review will examine the emerging idea that the gut microbiota plays a role in the development of hypertension, including that associated with OSA.
Disruption of the normal composition of the gut microbiota, termed dysbiosis, has been identified in a number of metabolic and cardiovascular diseases, including diabetes, obesity, and atherosclerosis. Recently, a number of studies have demonstrated gut dysbiosis in various animal models of hypertension as well as in hypertensive patients. Evidence is now emerging that gut dysbiosis plays a causal role in the development of OSA-induced hypertension. In this review, we will examine the evidence that gut dysbiosis plays a role in OSA-induced hypertension. We will discuss potential mechanisms linking OSA to gut dysbiosis, examine how gut dysbiosis may be linked to hypertension, and highlight how this understanding may be utilized for the development of future therapeutics.
阻塞性睡眠呼吸暂停（OSA）是全身性高血压和其他心血管疾病的重要危险因素。虽然这种关系已被确凿证实，但对于OSA如何导致高血压仍缺乏详细了解。本综述将探讨肠道微生物群在高血压（包括与OSA相关的高血压）发生发展中起作用这一新兴观点。
肠道微生物群正常组成的破坏，即生态失调，已在多种代谢和心血管疾病中被发现，包括糖尿病、肥胖症和动脉粥样硬化。最近，多项研究已证实在各种高血压动物模型以及高血压患者中存在肠道生态失调。现在有证据表明肠道生态失调在OSA诱发的高血压发生中起因果作用。在本综述中，我们将研究肠道生态失调在OSA诱发的高血压中起作用的证据。我们将讨论将OSA与肠道生态失调联系起来的潜在机制，研究肠道生态失调可能如何与高血压相关联，并强调这种认识如何可用于未来治疗方法的开发。
