Cadish Lauren A, Hacker Michele R, Modest Anna M, Rogers Kathleen J, Dessie Sybil, Elkadry Eman A
a Department of Obstetrics and Gynaecology , Beth Israel Deaconess Medical Centre , Boston , MA , USA.
b Department of Obstetrics, Gynaecology and Reproductive Biology , Harvard Medical School , Boston , MA , USA.
J Obstet Gynaecol. 2017 Aug;37(6):766-769. doi: 10.1080/01443615.2017.1292226. Epub 2017 Apr 1.
We aimed to prospectively evaluate the association between body mass index (BMI) and development of postoperative-onset pain in women undergoing transobturator midurethral sling procedures. We conducted a prospective, observational cohort study of women undergoing inside-to-out transobturator midurethral sling. At preoperative visit, height, weight, self-reported activity level and baseline pain were documented. At postoperative visits, patients indicated pain location and severity, procedure success, and satisfaction. We used log binomial regression to calculate risk ratios, controlling for potential confounders. For the 129 women included, median age was 50.0 years and BMI was 27.2 kg/m. Adjusting for age and activity level, overweight and obese women had significantly increased risk of postoperative-onset pain compared to normal BMI women. Overweight women were at 1.70 (95%CI 1.05-2.75) times the risk compared to leaner counterparts, whereas obese women were at 1.76 times the risk (95%CI 1.04-2.89). Neither success nor satisfaction was associated with BMI. Impact statement Over three million midurethral slings have been placed worldwide for the treatment or prevention of stress urinary incontinence. The procedure has been studied in lean, overweight and obese populations, and found to have similar efficacy regardless of BMI. Similarly, the risks of midurethral sling have been well-documented, including the risk of pain after transobturator sling. Little attention has been given to whether this risk of postoperative pain varies based on patient BMI. Our previous work suggesting that leaner patients might be at increased risk of postoperative pain following transobturator sling was limited by the shortcomings of a retrospective study design. In this prospective study, we were able to adjust for age and activity level, finding that higher BMI women were at increased risk of postoperative pain, while reporting similar levels of satisfaction with the procedure. Future research is needed to find what differences in anatomy or physiology can explain this finding. From a clinical standpoint, thorough counselling of all patients but particularly those with elevated BMI, is required so that appropriate expectations regarding recovery can be set preoperatively.
我们旨在前瞻性评估体重指数(BMI)与接受经闭孔尿道中段吊带术的女性术后疼痛发生之间的关联。我们对接受由内向外经闭孔尿道中段吊带术的女性进行了一项前瞻性观察队列研究。在术前访视时,记录身高、体重、自我报告的活动水平和基线疼痛情况。在术后访视时,患者指出疼痛部位和严重程度、手术成功率及满意度。我们使用对数二项回归来计算风险比,并对潜在混杂因素进行控制。纳入的129名女性中,年龄中位数为50.0岁,BMI为27.2kg/m²。在对年龄和活动水平进行调整后,超重和肥胖女性术后疼痛发生风险相较于BMI正常的女性显著增加。与较瘦女性相比,超重女性的风险是其1.70倍(95%置信区间1.05 - 2.75),而肥胖女性的风险是其1.76倍(95%置信区间1.04 - 2.89)。手术成功率和满意度均与BMI无关。影响声明全球已进行了超过三百万例尿道中段吊带术用于治疗或预防压力性尿失禁。该手术已在瘦、超重和肥胖人群中进行研究,发现无论BMI如何,疗效相似。同样,尿道中段吊带术的风险也有充分记录,包括经闭孔吊带术后疼痛的风险。对于术后疼痛风险是否因患者BMI而异,关注较少。我们之前的研究表明,较瘦患者经闭孔吊带术后疼痛风险可能增加,但受回顾性研究设计的缺点所限。在这项前瞻性研究中,我们能够对年龄和活动水平进行调整,发现BMI较高的女性术后疼痛风险增加,同时报告对该手术的满意度水平相似。未来需要开展研究以找出解剖学或生理学上的哪些差异可以解释这一发现。从临床角度来看,需要对所有患者,尤其是BMI升高的患者进行全面咨询,以便在术前设定关于恢复的适当预期。