Song Linyong, Ye Qiang, Ge Xueping, Misra Anil, Tamerler Candan, Spencer Paulette
University of Kansas, Bioengineering Research Center, 1530 W. 15th Street, Lawrence, KS 66045-7609, USA.
University of Kansas, Bioengineering Research Center, 1530 W. 15th Street, Lawrence, KS 66045-7609, USA.
Dent Mater. 2017 May;33(5):564-574. doi: 10.1016/j.dental.2017.03.013. Epub 2017 Mar 31.
To investigate the polymerization kinetics, neutralization behavior, and mechanical properties of amine-functionalized dental adhesive cured in the presence of zwitterionic monomer, methacryloyloxyethyl phosphorylcholine (MPC).
The control adhesive was a mixture based on HEMA/BisGMA/2-N-morpholinoethyl methacrylate (MEMA) (40/30/30, w/w/w). The control and experimental formulations containing MPC were characterized with regard to water miscibility of liquid resins, photopolymerization kinetics, water sorption and solubility, dynamic mechanical properties and leachables from the polymers (aged in ethanol). The neutralization behavior of the adhesives was determined by monitoring the pH of lactic acid (LA) solution.
The water miscibility decreased with increasing MPC amount. The water sorption of experimental copolymer specimen was greater than the control. The addition of 8wt% water led to improved photo-polymerization efficiency for experimental formulations at MPC of 2.5 and 5wt%, and significant reduction in the cumulative amounts of leached HEMA, BisGMA, and MEMA, i.e. 90, 60 and 50% reduction, respectively. The neutralization rate of MPC-containing adhesive was faster than control. The optimal MPC concentration in the formulations was 5wt%.
Incompatibility between MEMA and MPC led to a decrease in water miscibility of the liquid resins. Water (at 8wt%) in the MPC-containing formulations (2.5-5wt% MPC) led to higher DC, faster R and significant reduction in leached HEMA, BisGMA, and MEMA. The neutralization rate was enhanced with the addition of MPC in the amine-containing formulation. Promoting the neutralization capability of dentin adhesives could play an important role in reducing recurrent decay at the composite/tooth interface.
研究在两性离子单体甲基丙烯酰氧乙基磷酰胆碱（MPC）存在下固化的胺官能化牙科粘合剂的聚合动力学、中和行为和力学性能。
对照粘合剂是基于甲基丙烯酸羟乙酯/双酚A双甲基丙烯酸缩水甘油酯/甲基丙烯酸2-N-吗啉乙酯（MEMA）（40/30/30，w/w/w）的混合物。对含有MPC的对照配方和实验配方在液体树脂的水混溶性、光聚合动力学、吸水性和溶解性、动态力学性能以及聚合物中的可浸出物（在乙醇中老化）方面进行了表征。通过监测乳酸（LA）溶液的pH值来确定粘合剂的中和行为。
随着MPC含量的增加，水混溶性降低。实验共聚物试样的吸水率大于对照样。添加8wt%的水可提高MPC含量为2.5wt%和5wt%的实验配方的光聚合效率，并显著降低浸出的甲基丙烯酸羟乙酯、双酚A双甲基丙烯酸缩水甘油酯和甲基丙烯酸2-N-吗啉乙酯的累积量，即分别降低90%、60%和50%。含MPC粘合剂的中和速率比对照样快。配方中MPC的最佳浓度为5wt%。
MEMA与MPC之间的不相容性导致液体树脂的水混溶性降低。含MPC配方（2.5 - 5wt% MPC）中的水（8wt%）导致更高的转化率、更快的反应速率以及浸出的甲基丙烯酸羟乙酯、双酚A双甲基丙烯酸缩水甘油酯和甲基丙烯酸2-N-吗啉乙酯显著减少。在含胺配方中添加MPC可提高中和速率。提高牙本质粘合剂的中和能力在减少复合材料/牙齿界面的继发龋方面可能发挥重要作用。
