Toth Thomas L, Lee Malinda S, Bendikson Kristin A, Reindollar Richard H
Vincent Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Vincent Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Fertil Steril. 2017 Apr;107(4):1003-1011. doi: 10.1016/j.fertnstert.2016.10.040.
To better understand practice patterns and opportunities for standardization of ET.
Cross-sectional survey.
Not applicable.
PATIENT(S): Not applicable.
INTERVENTION(S): An anonymous 82-question survey was emailed to the medical directors of 286 Society for Assisted Reproductive Technology member IVF practices. A follow-up survey composed of three questions specific to ET technique was emailed to the same medical directors. Descriptive statistics of the results were compiled.
MAIN OUTCOME MEASURE(S): The survey assessed policies, protocols, restrictions, and specifics pertinent to the technique of ET.
RESULT(S): There were 117 (41%) responses; 32% practice in academic settings and 68% in private practice. Responders were experienced clinicians, half of whom had performed <10 procedures during training. Ninety-eight percent of practices allowed all practitioners to perform ET; half did not follow a standardized ET technique. Multiple steps in the ET process were identified as "highly conserved;" others demonstrated discordance. ET technique is divided among [1] trial transfer followed immediately with ET (40%); [2] afterload transfer (30%); and [3] direct transfer without prior trial or afterload (27%). Embryos are discharged in the upper (66%) and middle thirds (29%) of the endometrial cavity and not closer than 1-1.5 cm from fundus (87%). Details of each step were reported and allowed the development of a "common" practice ET procedure.
CONCLUSION(S): ET training and practices vary widely. Improved training and standardization based on outcomes data and best practices are warranted. A common practice procedure is suggested for validation by a systematic literature review.
为了更好地了解胚胎移植(ET)的实践模式及标准化机会。
横断面调查。
不适用。
不适用。
向286家辅助生殖技术协会成员体外受精(IVF)机构的医学主任发送了一份包含82个问题的匿名调查问卷。向同一批医学主任发送了一份由3个关于ET技术的特定问题组成的后续调查问卷。对结果进行描述性统计。
该调查评估了与ET技术相关的政策、方案、限制和细节。
共收到117份(41%)回复;32%的机构为学术机构,68%为私人机构。回复者均为经验丰富的临床医生,其中一半在培训期间进行的操作少于10例。98%的机构允许所有从业者进行ET操作;一半的机构未遵循标准化的ET技术。ET过程中的多个步骤被确定为“高度一致”;其他步骤则存在差异。ET技术分为以下几种:[1]试移植后立即进行ET(40%);[2]后置移植(30%);[3]无预先试移植或后置移植的直接移植(27%)。胚胎被放置在子宫内膜腔的上三分之一(66%)和中三分之一(29%),距离宫底不小于1 - 1.5厘米(87%)。报告了每个步骤的细节,并据此制定了一个“通用”的ET实践程序。
ET培训和实践差异很大。基于结果数据和最佳实践改进培训及标准化是有必要的。建议采用一个通用的实践程序,通过系统的文献综述进行验证。