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胚胎移植技术:美国生殖医学学会对辅助生殖技术协会当前实践的调查

Embryo transfer techniques: an American Society for Reproductive Medicine survey of current Society for Assisted Reproductive Technology practices.

作者信息

Toth Thomas L, Lee Malinda S, Bendikson Kristin A, Reindollar Richard H

机构信息

Vincent Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Vincent Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

出版信息

Fertil Steril. 2017 Apr;107(4):1003-1011. doi: 10.1016/j.fertnstert.2016.10.040.

Abstract

OBJECTIVE

To better understand practice patterns and opportunities for standardization of ET.

DESIGN

Cross-sectional survey.

SETTING

Not applicable.

PATIENT(S): Not applicable.

INTERVENTION(S): An anonymous 82-question survey was emailed to the medical directors of 286 Society for Assisted Reproductive Technology member IVF practices. A follow-up survey composed of three questions specific to ET technique was emailed to the same medical directors. Descriptive statistics of the results were compiled.

MAIN OUTCOME MEASURE(S): The survey assessed policies, protocols, restrictions, and specifics pertinent to the technique of ET.

RESULT(S): There were 117 (41%) responses; 32% practice in academic settings and 68% in private practice. Responders were experienced clinicians, half of whom had performed <10 procedures during training. Ninety-eight percent of practices allowed all practitioners to perform ET; half did not follow a standardized ET technique. Multiple steps in the ET process were identified as "highly conserved;" others demonstrated discordance. ET technique is divided among [1] trial transfer followed immediately with ET (40%); [2] afterload transfer (30%); and [3] direct transfer without prior trial or afterload (27%). Embryos are discharged in the upper (66%) and middle thirds (29%) of the endometrial cavity and not closer than 1-1.5 cm from fundus (87%). Details of each step were reported and allowed the development of a "common" practice ET procedure.

CONCLUSION(S): ET training and practices vary widely. Improved training and standardization based on outcomes data and best practices are warranted. A common practice procedure is suggested for validation by a systematic literature review.

摘要

目的

为了更好地了解胚胎移植(ET)的实践模式及标准化机会。

设计

横断面调查。

地点

不适用。

患者

不适用。

干预措施

向286家辅助生殖技术协会成员体外受精(IVF)机构的医学主任发送了一份包含82个问题的匿名调查问卷。向同一批医学主任发送了一份由3个关于ET技术的特定问题组成的后续调查问卷。对结果进行描述性统计。

主要观察指标

该调查评估了与ET技术相关的政策、方案、限制和细节。

结果

共收到117份(41%)回复;32%的机构为学术机构,68%为私人机构。回复者均为经验丰富的临床医生,其中一半在培训期间进行的操作少于10例。98%的机构允许所有从业者进行ET操作;一半的机构未遵循标准化的ET技术。ET过程中的多个步骤被确定为“高度一致”;其他步骤则存在差异。ET技术分为以下几种:[1]试移植后立即进行ET(40%);[2]后置移植(30%);[3]无预先试移植或后置移植的直接移植(27%)。胚胎被放置在子宫内膜腔的上三分之一(66%)和中三分之一(29%),距离宫底不小于1 - 1.5厘米(87%)。报告了每个步骤的细节,并据此制定了一个“通用”的ET实践程序。

结论

ET培训和实践差异很大。基于结果数据和最佳实践改进培训及标准化是有必要的。建议采用一个通用的实践程序,通过系统的文献综述进行验证。

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