Nousiainen U, Partanen J, Laulumaa V, Paljärvi L
Department of Clinical Neurophysiology, University Central Hospital of Kuopio, Finland.
Muscle Nerve. 1988 May;11(5):478-83. doi: 10.1002/mus.880110511.
We studied 10 patients with late onset spinocerebellar ataxia including electrophysiological and muscle biopsy examinations. Nerve conduction studies of eight patients revealed axonal neuropathy, and six cases also showed signs of the involvement of the lower motor neuron. In 9 patients quantitative analysis of single motor unit potentials (MUPs) of the tibialis anterior or biceps brachii muscles showed mild to severe neuropathic changes and in all 10 patients the histopathological examination of the tibialis anterior showed mild to severe neuropathic changes. Neither nerve conduction studies, quantitative MUP analysis, nor histological findings of the muscle were related to the severity of duration of the disease.
我们研究了10例迟发性脊髓小脑共济失调患者，包括进行电生理和肌肉活检检查。8例患者的神经传导研究显示存在轴索性神经病，6例还表现出下运动神经元受累的迹象。9例患者的胫前肌或肱二头肌单运动单位电位（MUP）定量分析显示有轻度至重度的神经病变改变，所有10例患者的胫前肌组织病理学检查均显示有轻度至重度的神经病变改变。神经传导研究、MUP定量分析以及肌肉的组织学检查结果均与疾病的严重程度和病程无关。
