Patel Niki R, Kelly Christopher B, Siegenfeld Allison P, Molander Gary A
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
ACS Catal. 2017 Mar 3;7(3):1766-1770. doi: 10.1021/acscatal.6b03665. Epub 2017 Feb 6.
An operationally simple, mild, redox-neutral method for the photoredox alkylation of imines is reported. Utilizing an inexpensive organic photoredox catalyst, alkyl radicals are readily generated from the single-electron oxidation of ammonium alkyl bis(catecholato)silicates and are subsequently engaged in a C-C bond-forming reaction with imines. The process is highly selective, metal-free, and does not require a large excess of the alkylating reagent or the use of acidic additives.
报道了一种操作简单、温和、氧化还原中性的亚胺光催化烷基化方法。利用一种廉价的有机光氧化还原催化剂，烷基自由基可通过烷基双（儿茶酚）硅酸铵的单电子氧化轻松生成，随后与亚胺发生碳-碳键形成反应。该过程具有高度选择性、无金属，且不需要大量过量的烷基化试剂或使用酸性添加剂。
