1,4-二氢吡啶作为烷基自由基前体：将醛类原料引入镍/光氧化还原双催化体系
1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis.
作者信息
Gutiérrez-Bonet Álvaro, Tellis John C, Matsui Jennifer K, Vara Brandon A, Molander Gary A
机构信息
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
出版信息
ACS Catal. 2016 Dec 2;6(12):8004-8008. doi: 10.1021/acscatal.6b02786. Epub 2016 Oct 27.
A Ni/photoredox dual catalytic cross-coupling is disclosed in which a diverse range of (hetero)aryl bromides are used as electrophiles, with 1,4-dihydropyridines serving as precursors to C-centered alkyl radical coupling partners. The reported method is characterized by its extremely mild reaction conditions, enabling access to underexplored cores.
公开了一种镍/光氧化还原双催化交叉偶联反应，其中多种（杂）芳基溴化物用作亲电试剂，1,4-二氢吡啶作为碳中心烷基自由基偶联伙伴的前体。所报道的方法的特点是反应条件极其温和，能够合成尚未充分探索的核心结构。
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