Sasa M, Komaki K, Morimoto T, Mori T, Miki H, Uyama T, Monden Y
Department of Surgery, National Sanatorium, Tokushima Hospital, Shikiji, Kamojima-cho, Oe-gun, Tokushima 776, Japan.
Breast Cancer. 1994 Jul 30;1(1):31-36. doi: 10.1007/BF02967372.
To identify the characteristics of cases with an wide intraductal cancerous extension (WICE), we examined the relationship between WICE and type IV collagen distribution, and the relationship between WICE and the content of the proliferation-associated proteins in human breast cancer. The immunohistochemical distribution of type IV collagen and proliferating cell nuclear antigen (PCNA) were investigated in formalin-fixed tissue sections from 21 breast cancer cases. We demonstrated a significant correlation (p=0.014) between the presence of WICE and immunostaining of type IV collagen in the cancerous ducts (ducts occupied by cancer cells) in the central invasive area of breast cancer. However, no correlation was found between the presence of WICE and the PCNA index (percentage of positive cells per 1000 tumor cells). These findings suggest that the lack of the process of the loss of type IV collagen in the duct wall is more important than the nature of the tumor cells in the development of WICE.
为了确定导管内癌广泛扩展（WICE）病例的特征，我们研究了WICE与IV型胶原分布之间的关系，以及WICE与人类乳腺癌中增殖相关蛋白含量之间的关系。对21例乳腺癌病例的福尔马林固定组织切片进行了IV型胶原和增殖细胞核抗原（PCNA）的免疫组化分布研究。我们发现，在乳腺癌中央浸润区域的癌性导管（被癌细胞占据的导管）中，WICE的存在与IV型胶原免疫染色之间存在显著相关性（p=0.014）。然而，未发现WICE的存在与PCNA指数（每1000个肿瘤细胞中阳性细胞的百分比）之间存在相关性。这些发现表明，在WICE的发生过程中，导管壁IV型胶原缺失过程的缺失比肿瘤细胞的性质更为重要。
