中国皮革行业工人队列中低剂量N，N-二甲基甲酰胺暴露与肝脏损伤
Low-Dose N,N-Dimethylformamide Exposure and Liver Injuries in a Cohort of Chinese Leather Industry Workers.
作者信息
Qi Cong, Gu Yiyang, Sun Qing, Gu Hongliang, Xu Bo, Gu Qing, Xiao Jing, Lian Yulong
机构信息
Division of Occupational and Environment Health, College of Public Health, Nantong (Ms Qi, Ms Gu, Ms Sun, Dr Xiao, Dr Lian); and Division of Tai cang Center for Disease Control and Prevention, Tai cang, Suzhou (Mr Gu, Mr Xu, Ms Gu), Jiangsu, China.
出版信息
J Occup Environ Med. 2017 May;59(5):434-439. doi: 10.1097/JOM.0000000000000983.
OBJECTIVE
We assessed the risk of liver injuries following low doses of N,N-dimethylformamide (DMF) below threshold limit values (20 mg/m) among leather industry workers and comparison groups.
METHODS
A cohort of 429 workers from a leather factory and 466 non-exposed subjects in China were followed for 4 years. Poisson regression and piece-wise linear regression were used to examine the relationship between DMF and liver injury.
RESULTS
Workers exposed to a cumulative dose of DMF were significantly more likely than non-exposed workers to develop liver injury. A nonlinear relationship between DMF and liver injury was observed, and a threshold of the cumulative DMF dose for liver injury was 7.30 (mg/m) year.
CONCLUSIONS
The findings indicate the importance of taking action to reduce DMF occupational exposure limits for promoting worker health.
目的
我们评估了皮革行业工人及对照组在低于阈限值（20毫克/立方米）的低剂量N，N - 二甲基甲酰胺（DMF）暴露后发生肝损伤的风险。
方法
对中国一家皮革厂的429名工人和466名未暴露者进行了为期4年的随访。采用泊松回归和分段线性回归分析DMF与肝损伤之间的关系。
结果
累积接触DMF的工人发生肝损伤的可能性显著高于未接触工人。观察到DMF与肝损伤之间存在非线性关系，肝损伤的累积DMF剂量阈值为7.30（毫克/立方米）·年。
结论
研究结果表明采取行动降低DMF职业接触限值对促进工人健康的重要性。
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