Wahl C, Hedinger C
Institut für Pathologie der Universität Zürich.
Schweiz Med Wochenschr. 1988 Mar 26;118(12):427-33.
Before the introduction of effective chemotherapy for testicular germ cell tumours, the relative frequency of bilateral germ cell tumours was about 1.6%. Now, as more patients with unilateral tumours survive, an increase in this percentage is to be expected. We therefore compared a series of 397 patients with testicular germ cell tumours observed between 1950-1975 with a series of 333 patients with such tumours observed between 1976-1985, after the introduction of chemotherapy with cis-platinum. In both series 7 patients had bilateral germ cell tumours, i.e. 1.8% of cases in the first series and 2.1% of cases in the second series. Since the second series of cases with a much shorter follow-up has an unbalanced ratio of seminomatous to non-seminomatous tumours, an increase in bilaterality can be expected. The prophylactic and therapeutic implications of an increase in bilateral germ cell tumours of the testis are discussed.
在针对睾丸生殖细胞肿瘤的有效化疗方法出现之前，双侧生殖细胞肿瘤的相对发生率约为1.6%。如今，随着更多单侧肿瘤患者存活下来，可以预期这一百分比会上升。因此，我们将1950年至1975年间观察到的397例睾丸生殖细胞肿瘤患者与1976年至1985年间观察到的333例此类肿瘤患者进行了比较，后者是在引入顺铂化疗之后。在这两个系列中，均有7例患者患有双侧生殖细胞肿瘤，即第一个系列中占病例的1.8%，第二个系列中占病例的2.1%。由于第二个系列病例的随访时间短得多，精原细胞瘤与非精原细胞瘤的比例不均衡，因此可以预期双侧性会增加。本文讨论了睾丸双侧生殖细胞肿瘤增加的预防和治疗意义。
