Tianjin Key Laboratory of Metabolic Diseases; Collaborative Innovation Center of Tianjin for Medical Epigenetics; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.
Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, 300070, China.
Br J Pharmacol. 2018 Apr;175(8):1354-1361. doi: 10.1111/bph.13806. Epub 2017 May 10.
Vascular remodelling is a vital process of a wide range of cardiovascular diseases and represents the altered structure and arrangement of blood vessels. The Hippo pathway controls organ size by regulating cell survival, proliferation and apoptosis. Yes-associated protein (YAP), a transcription coactivator, is a downstream effector of the Hippo pathway. There is growing evidence for the importance of the Hippo/YAP pathway in vascular-remodelling and related cardiovascular diseases. The Hippo/YAP pathway alters extracellular matrix production or degradation and the growth, death and migration of vascular smooth muscle cells and endothelial cells, which contributes to vascular remodelling in cardiovascular diseases such as pulmonary hypertension, atherosclerosis, restenosis, aortic aneurysms and angiogenesis. In this review, we summarize and discuss recent findings about the roles and mechanisms of Hippo/YAP signalling in vascular remodelling and related conditions.
This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc.
血管重构是广泛的心血管疾病的重要过程，代表了血管的结构和排列的改变。 Hippo 通路通过调节细胞存活、增殖和凋亡来控制器官大小。 Yes 相关蛋白（YAP）是 Hippo 通路的下游效应物，是一种转录共激活因子。越来越多的证据表明 Hippo/YAP 通路在血管重构和相关心血管疾病中的重要性。 Hippo/YAP 通路改变细胞外基质的产生或降解以及血管平滑肌细胞和内皮细胞的生长、死亡和迁移，这有助于肺动脉高压、动脉粥样硬化、再狭窄、主动脉瘤和血管生成等心血管疾病中的血管重构。在这篇综述中，我们总结和讨论了 Hippo/YAP 信号在血管重构和相关疾病中的作用和机制的最新发现。
本文是心血管疾病小分子聚焦专题的一部分。要查看本部分中的其他文章，请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc.
