Department of Cardiology and Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Front Immunol. 2022 Aug 18;13:971416. doi: 10.3389/fimmu.2022.971416. eCollection 2022.
The Hippo pathway was initially discovered in and mammals as a key regulator of tissue growth both in physiological and pathological states. Numerous studies depict the vital role of the Hippo pathway in cardiovascular development, heart regeneration, organ size and vascular remodeling through the regulation of YAP (yes-associated protein) translocation. Recently, an increasing number of studies have focused on the Hippo-YAP pathway in inflammation and immunology. Although the Hippo-YAP pathway has been revealed to play controversial roles in different contexts and cell types in the cardiovascular system, the mechanisms regulating tissue inflammation and the immune response remain to be clarified. In this review, we summarize findings from the past decade on the function and mechanism of the Hippo-YAP pathway in CVDs (cardiovascular diseases) such as myocardial infarction, cardiomyopathy and atherosclerosis. In particular, we emphasize the role of the Hippo-YAP pathway in regulating inflammatory cell infiltration and inflammatory cytokine activation.
Hippo 通路最初在 和哺乳动物中被发现，是生理和病理状态下组织生长的关键调节剂。大量研究表明 Hippo 通路通过调节 YAP（Yes 相关蛋白）易位在心血管发育、心脏再生、器官大小和血管重塑中发挥重要作用。最近，越来越多的研究关注 Hippo-YAP 通路在炎症和免疫学中的作用。尽管 Hippo-YAP 通路在心血管系统的不同背景和细胞类型中发挥着有争议的作用，但调节组织炎症和免疫反应的机制仍有待阐明。在这篇综述中，我们总结了过去十年关于 Hippo-YAP 通路在心血管疾病（如心肌梗死、心肌病和动脉粥样硬化）中的功能和机制的研究结果。特别是，我们强调了 Hippo-YAP 通路在调节炎症细胞浸润和炎症细胞因子激活中的作用。
