Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.
Department of Information, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.
Int J Cancer. 2017 Jul 1;141(1):152-159. doi: 10.1002/ijc.30719. Epub 2017 Apr 24.
Several non-hepatocellular cancers were linked with hepatitis B virus (HBV) infection. This study was aimed to quantify the potential associations between HBV infection and multiple non-hepatocellular cancers. Continuous cases, including 5,715 non-cancer and 40,963 cancer cases diagnosed from 2008 to 2014 in Sun Yat-sen University Cancer Center were analyzed. HBV DNA and hepatitis B core antigen (HBcAg) were examed in gastric cancer tissues by polymerase chain reaction and immunohistochemical staining. After adjusting for age, sex, year of diagnosis, smoking, drinking and family history of cancer, significant associations were found between serum HBsAg and frequently reported HBV-related non-hepatocellular cancers, including non-Hodgkin's lymphoma, cholangiocarcinoma and pancreatic cancer [adjusted odds ratio (AOR) and 95% confidence interval (CI): 1.89 (1.65-2.16)], as well as total other non-hepatocellular cancers [AOR and 95% CI: 1.12 (1.03-1.22)]. The median ages at diagnosis, all-cause death and cancer-specific death of serum HBsAg positive cancer patients were all significantly younger than those with serum HBsAg negative. HBV DNA was detected in 12.4% (34/275) gastric cancer tissues and HBcAg was most commonly detected in lymphocytes. This was the first report that HBV infection had a modest but significant nonspecific association with total non-hepatocellular cancers. Median age at diagnosis and death was significantly younger in serum HBsAg positive cancer patients. The underlying mechanism needs further investigation.
多种非肝细胞癌与乙型肝炎病毒（HBV）感染有关。本研究旨在定量评估 HBV 感染与多种非肝细胞癌之间的潜在关联。分析了中山大学肿瘤防治中心 2008 年至 2014 年间连续收治的 5715 例非癌症和 40963 例癌症患者。通过聚合酶链反应和免疫组织化学染色检测胃癌组织中的 HBV DNA 和乙型肝炎核心抗原（HBcAg）。在校正年龄、性别、诊断年份、吸烟、饮酒和癌症家族史后，发现血清 HBsAg 与常见报道的 HBV 相关非肝细胞癌（包括非霍奇金淋巴瘤、胆管癌和胰腺癌）之间存在显著关联[调整后的优势比（AOR）和 95%置信区间（CI）：1.89（1.65-2.16）]，以及所有其他非肝细胞癌[AOR 和 95%CI：1.12（1.03-1.22）]。血清 HBsAg 阳性癌症患者的诊断年龄、全因死亡和癌症特异性死亡的中位年龄均明显低于血清 HBsAg 阴性患者。在 275 例胃癌组织中检测到 12.4%（34/275）的 HBV DNA，HBcAg 最常见于淋巴细胞中。这是首次报道 HBV 感染与总非肝细胞癌具有适度但显著的非特异性关联。血清 HBsAg 阳性癌症患者的诊断和死亡中位年龄明显更低。其潜在机制需要进一步研究。
