计算机断层扫描正常的工人中，肺功能不受石棉暴露影响。
Lung function not affected by asbestos exposure in workers with normal Computed Tomography scan.
作者信息
Schikowsky Christian, Felten Michael K, Eisenhawer Christian, Das Marco, Kraus Thomas
机构信息
Institute for Occupational and Social Medicine, RWTH Aachen University, Aachen, Germany.
Department of Diagnostic Radiology, RWTH Aachen University, Aachen, Germany.
出版信息
Am J Ind Med. 2017 May;60(5):422-431. doi: 10.1002/ajim.22717. Epub 2017 Mar 30.
BACKGROUND
It has been suggested that asbestos exposure affects lung function, even in the absence of asbestos-related pulmonary interstitial or pleural changes or emphysema.
METHODS
We analyzed associations between well-known asbestos-related risk factors, such as individual cumulative asbestos exposure, and key lung function parameters in formerly asbestos-exposed power industry workers (N = 207) with normal CT scans. For this, we excluded participants with emphysema, fibrosis, pleural changes, or any combination of these.
RESULTS
The lung function parameters of FVC, FEV1, DLCO/VA, and airway resistance were significantly associated with the burden of smoking, BMI and years since end of exposure (only DLCO/VA). However, they were not affected by factors directly related to amount (eg, cumulative exposure) or duration of asbestos exposure.
CONCLUSIONS
Our results confirm the well-known correlation between lung function, smoking habits, and BMI. However, we found no significant association between lung function and asbestos exposure.
背景
有人提出，即使在没有与石棉相关的肺间质或胸膜改变或肺气肿的情况下，接触石棉也会影响肺功能。
方法
我们分析了著名的与石棉相关的危险因素，如个体累积石棉暴露量，与胸部CT扫描正常的既往接触石棉的电力行业工人（N = 207）的关键肺功能参数之间的关联。为此，我们排除了患有肺气肿、纤维化、胸膜改变或这些情况的任何组合的参与者。
结果
FVC、FEV1、DLCO/VA和气道阻力等肺功能参数与吸烟负担、BMI以及接触结束后的年限（仅DLCO/VA）显著相关。然而，它们不受与石棉接触量（如累积暴露量）或接触持续时间直接相关的因素影响。
结论
我们的结果证实了肺功能、吸烟习惯和BMI之间众所周知的相关性。然而，我们发现肺功能与石棉暴露之间没有显著关联。
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