Peng H Q, Roth P, Caussy D, Rawls W
Department of Pathology, McMaster University, Hamilton, Ontario, Canada.
Acta Cytol. 1988 May-Jun;32(3):311-3.
The Cytobrush was compared with the cotton swab for collecting samples used to detect human papillomavirus (HPV) types 16 and 18 DNA by filter in situ hybridization. The study design entailed collecting two endocervical and one vaginal fornix sample from each of 200 women admitted to a colposcopy clinic. No difference was found in the HPV positivity rates in samples obtained with the two collection instruments. There was good agreement (91.5%) in the detection of viral DNA between the first and second endocervical samples; however, 15% of the patients with positive samples had detectable DNA in their second sample only. Significantly fewer samples from the fornix contained detectable HPV-16 or HPV-18 DNA than did endocervical samples.
将Cytobrush与棉拭子进行比较，通过滤膜原位杂交收集用于检测16型和18型人乳头瘤病毒（HPV）DNA的样本。研究设计要求从200名入住阴道镜检查诊所的女性中，每人采集两份宫颈管内膜样本和一份阴道穹窿样本。使用两种采集工具获得的样本中HPV阳性率没有差异。在首次和第二次宫颈管内膜样本之间，病毒DNA检测结果具有良好的一致性（91.5%）；然而，15%的样本呈阳性的患者仅在其第二次样本中检测到DNA。与宫颈管内膜样本相比，穹窿处样本中可检测到HPV-16或HPV-18 DNA的样本明显更少。
