Powell W S, McKenzie H J
Division of Gynecology, Hahnemann University Hospital, Philadelphia, PA 19102-1192.
J Reprod Med. 1992 Jun;37(6):525-8.
Cervical swab sampling for DNA hybridization was performed on 89 women attending a colposcopy clinic. In situ hybridization studies for human papillomavirus (HPV) types 6/11, 16/18 and 31/33/35 were performed on the specimens. Biopsy specimens were obtained from 65 patients. The cytologic, colposcopic and histologic results were classified into five groups and assigned a score of 0-5, depending upon the diagnosis. An increasing score correlated positively with the presence of HPV, especially types 16/18 and 31/33/35. A comparison was made of the sensitivity, specificity, and positive and negative predictive values for the standard method of colposcopic evaluation versus the standard method combined with DNA cervical swab sampling. No significant changes in the parameters were found when the DNA cervical swab was added.
对89名前往阴道镜检查门诊的女性进行了宫颈拭子DNA杂交采样。对标本进行了人乳头瘤病毒（HPV）6/11型、16/18型和31/33/35型的原位杂交研究。从65名患者身上获取了活检标本。根据诊断结果，将细胞学、阴道镜检查和组织学结果分为五组，并给予0至5分的评分。评分增加与HPV的存在呈正相关，尤其是16/18型和31/33/35型。对阴道镜评估标准方法与结合DNA宫颈拭子采样的标准方法的敏感性、特异性以及阳性和阴性预测值进行了比较。添加DNA宫颈拭子时，未发现参数有显著变化。
