视网膜母细胞瘤幸存者中的非眼部癌症。

Non-ocular cancer in retinoblastoma survivors.

作者信息

Winther J, Olsen J H

机构信息

Department of Ophthalmology, University Hospital Aarhus, Denmark.

出版信息

Acta Ophthalmol Suppl (1985). 1987;182:144-7. doi: 10.1111/j.1755-3768.1987.tb02615.x.

DOI:10.1111/j.1755-3768.1987.tb02615.x

PMID:2837050

Abstract

The risk of non-ocular cancer has been investigated in 150 surviving Danish patients with retinoblastoma diagnosed in the period 1943-1984. None of the patients had been treated with chemotherapeutic drugs. The overall relative risk of non-ocular cancer was 4.2 (95% confidence limits, 1.1-11.5). In the subgroups of hereditary retinoblastoma, the relative risk was 15.4 (95% confidence limits, 2.6-50.8), and in the subgroups of non-hereditary retinoblastoma the relative risk was 1.7 (95% confidence limits (0.1-8.5). The risk of cancer among 267 parents of retinoblastoma children was not different from that of the general population.

摘要

对1943年至1984年期间确诊的150名存活的丹麦视网膜母细胞瘤患者的非眼癌风险进行了调查。这些患者均未接受过化疗药物治疗。非眼癌的总体相对风险为4.2（95%置信区间，1.1 - 11.5）。在遗传性视网膜母细胞瘤亚组中，相对风险为15.4（95%置信区间，2.6 - 50.8），在非遗传性视网膜母细胞瘤亚组中，相对风险为1.7（95%置信区间，0.1 - 8.5）。视网膜母细胞瘤患儿的267名父母患癌风险与普通人群无异。