遗传性视网膜母细胞瘤幸存者及其亲属的非眼癌

Non-ocular cancer in hereditary retinoblastoma survivors and relatives.

作者信息

Derkinderen D J, Koten J W, Wolterbeek R, Beemer F A, Tan K E, Den Otter W

出版信息

Ophthalmic Paediatr Genet. 1987 Mar;8(1):23-5. doi: 10.3109/13816818709028511.

Abstract

An epidemiological survey has been carried out to establish the incidence of second malignant neoplasms in hereditary retinoblastoma survivors in The Netherlands and the relative risk of cancer in non-affected relatives. The cumulative incidence of second neoplasms was 19% at the age of 35 years. Fathers, unaffected by retinoblastoma, were at risk for pancreatic cancer, the relative risk being 8.3.

摘要

荷兰开展了一项流行病学调查，以确定遗传性视网膜母细胞瘤幸存者中第二原发性恶性肿瘤的发病率以及未受影响亲属患癌的相对风险。35岁时第二原发性肿瘤的累积发病率为19%。未患视网膜母细胞瘤的父亲患胰腺癌的风险较高，相对风险为8.3。