视网膜母细胞瘤患者及其父母患非眼部癌症的风险。丹麦一项基于人群的研究，1943 - 1984年。

Risk of nonocular cancer among retinoblastoma patients and their parents. A population-based study in Denmark, 1943-1984.

作者信息

Winther J, Olsen J H, de Nully Brown P

机构信息

Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus.

出版信息

Cancer. 1988 Oct 1;62(7):1458-62. doi: 10.1002/1097-0142(19881001)62:7<1458::aid-cncr2820620735>3.0.co;2-2.

DOI:10.1002/1097-0142(19881001)62:7<1458::aid-cncr2820620735>3.0.co;2-2

PMID:3416285

Abstract

The risk of nonocular cancer among survivors of retinoblastoma has been investigated in a population-based study in Denmark, 1943 to 1984. None of the survivors had been treated with chemotherapeutic drugs. Forty-eight patients were treated with x-rays, and 102 patients were treated primarily with surgical removal of the eye(s). The overall relative risk (RR) for a new primary cancer was 4.2 (95% confidence limits, 1.1-11.5). In the subgroup of genetic retinoblastoma the risk was 15.4 (95% confidence limits, 2.6-50.8) and in the group of nonhereditary cancer the risk was 1.7 (95% confidence limits, 0.1-8.5). For all retinoblastoma patients the RR of bone cancer was 100 (95% confidence limits, 17-330). Parents not having retinoblastoma themselves were not at increased risk for nonocular cancer.

摘要

1943年至1984年期间，丹麦开展了一项基于人群的研究，调查了视网膜母细胞瘤幸存者患非眼癌的风险。所有幸存者均未接受过化疗药物治疗。48例患者接受了X射线治疗，102例患者主要接受了眼球手术摘除。新发原发性癌症的总体相对风险（RR）为4.2（95%置信区间，1.1 - 11.5）。在遗传性视网膜母细胞瘤亚组中，风险为15.4（95%置信区间，2.6 - 50.8），在非遗传性癌症组中，风险为1.7（95%置信区间，0.1 - 8.5）。对于所有视网膜母细胞瘤患者，骨癌的RR为100（95%置信区间，17 - 330）。自身没有患视网膜母细胞瘤的父母患非眼癌的风险并未增加。