使用一种顺磁化学交换饱和转移（ParaCEST）磁共振成像（MRI）造影剂检测DT-黄递酶
Detection of DT-diaphorase Enzyme with a ParaCEST MRI Contrast Agent.
作者信息
Daryaei Iman, Jones Kyle M, Pagel Mark D
机构信息
Department of Chemistry and Biochemistry, University of Arizona, 1306 E. University Blvd., Room 221, Tucson, Arizona, 85721-0041, USA.
Department of Biomedical Engineering, University of Arizona, 1127 E James E. Rogers Way P.O. Box 210020, Tucson, AZ, 85721-0020, USA.
出版信息
Chemistry. 2017 May 11;23(27):6514-6517. doi: 10.1002/chem.201700721. Epub 2017 Apr 20.
A responsive magnetic resonance (MRI) contrast agent has been developed that can detect the enzyme activity of DT-diaphorase. The agent produced different chemical exchange saturation transfer (CEST) MRI signals before and after incubation with the enzyme, NADH, and GSH at different pH values whereas it showed good stability in a reducing environment without enzyme.
一种能够检测DT-黄递酶酶活性的响应性磁共振（MRI）造影剂已被研发出来。该造影剂在不同pH值下与酶、NADH和GSH孵育前后产生了不同的化学交换饱和转移（CEST）MRI信号，而在无酶的还原环境中表现出良好的稳定性。
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