Edwards Meghan K, Loprinzi Paul D
Physical Activity Epidemiology Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, University, Mississippi, 38677.
Jackson Heart Study Vanguard Center of Oxford, Physical Activity Epidemiology Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, University, Mississippi, 38677.
Am J Hum Biol. 2017 Sep 10;29(5). doi: 10.1002/ajhb.23001. Epub 2017 Mar 28.
To evaluate the association of the Fat-but-Fit paradigm with cognitive function in an older adult population.
Data from the 1999-2002 National Health and Nutrition Examination Survey were used (N = 2,336 adults 60-85 yrs). Physical activity was assessed via open-ended questions asking about participation in 48 leisure-time activities over the previous 30 days. Using Metabolic Equivalent of Task calculations for each activity, participants were classified as either active or inactive. Participants were then classified into one of six groups (Normal BMI and Inactive [referent], Overweight BMI and Inactive, Obese BMI and Inactive, Normal BMI and Active, Overweight BMI and Active, Obese BMI and Active), based on their activity status and body mass index (BMI). The Digit Symbol Substitution Test (DSST) was employed to assess cognitive function.
Compared to those who had a normal BMI and were inactive (referent), those who had a normal BMI and were active had a 4-unit higher DSST score (β = 4.0; 95% CI: 1.0-6.9; P = 0.009); those with an overweight BMI and active had a 4.5-unit higher DSST score (β = 4.5; 95% CI: 1.3-7.6; P = 0.008); and those who had an obese BMI and active had a 3.7-unit higher DSST score (β = 3.7; 95% CI: 0.96-6.4; P = 0.01).
Being active, regardless of weight classification (normal, overweight, or obese) was positively associated with cognitive function in this sample of older adults. This suggests that perhaps the best strategy to promote cognitive health in this population may be to encourage adequate levels of physical activity.
评估“胖但健康”模式与老年人群认知功能之间的关联。
使用1999 - 2002年国家健康与营养检查调查的数据（N = 2336名60 - 85岁的成年人）。通过开放式问题评估身体活动情况，询问过去30天参与48项休闲活动的情况。利用每项活动的代谢当量计算，将参与者分为活跃或不活跃两类。然后根据参与者的活动状态和体重指数（BMI），将其分为六组之一（正常BMI且不活跃[参照组]、超重BMI且不活跃、肥胖BMI且不活跃、正常BMI且活跃、超重BMI且活跃、肥胖BMI且活跃）。采用数字符号替换测验（DSST）评估认知功能。
与BMI正常且不活跃的人（参照组）相比，BMI正常且活跃的人DSST得分高4分（β = 4.0；95%置信区间：1.0 - 6.9；P = 0.009）；超重BMI且活跃的人DSST得分高4.5分（β = 4.5；95%置信区间：1.3 - 7.6；P = 0.008）；肥胖BMI且活跃的人DSST得分高3.7分（β = 3.7；95%置信区间：0.96 - 6.4；P = 0.01）。
在这个老年人群样本中，无论体重分类（正常、超重或肥胖），保持活跃都与认知功能呈正相关。这表明，在该人群中促进认知健康的最佳策略可能是鼓励适当水平的身体活动。
