Frith Emily, Loprinzi Paul D
Jackson Heart Study Vanguard Center of Oxford, Physical Activity Epidemiology Laboratory, Exercise Psychology Laboratory School of Applied Sciences, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, Oxford, Mississippi, USA.
J Hypertens. 2017 Jun;35(6):1271-1275. doi: 10.1097/HJH.0000000000001311.
We evaluated the specific association between physical activity and cognitive function among a national sample of the broader US adult population with evidence of systemic hypertension.
Data from the 1999-2002 National Health and Nutrition Examination Survey were used to identify 1554 older adults, aged 60-85 years, with evidence of hypertension. The Digit Symbol Substitution Test (DSST) was used to assess cognitive function tasks of pairing and free recall among participants. Participants were asked open-ended questions about participation in leisure-time physical activity over the past 30 days. For each of the activities, metabolic equivalent of task-min-month were calculated. Those at or above 2000 metabolic equivalent of task-min-month (equivalent to 150 min/week) were defined as physically active.
In an unadjusted weighted multivariable linear regression model, those meeting moderate-to-vigorous physical activity guidelines (vs. not) had a DSST score 8.3 units higher (β = 8.3; 95% confidence interval: 5.9-10.7; P < 0.001). After adjusting for age, sex, race-ethnicity, smoking status, energy intake, weight status, HDL cholesterol, total cholesterol, cholesterol medication status, glycated hemoglobin, diabetes medication status, and blood pressure medication status, those meeting moderate-to-vigorous physical activity guidelines (vs. not) had a DSST score 6.23 units higher (β = 6.23; 95% confidence interval: 4.6-7.9; P < 0.001).
In this national sample of hypertensive older adults, meeting physical activity guidelines was associated with higher cognitive function.
我们在美国成年人群体的全国样本中评估了身体活动与认知功能之间的特定关联，这些人群有系统性高血压的证据。
使用1999 - 2002年国家健康和营养检查调查的数据，识别出1554名60 - 85岁有高血压证据的老年人。数字符号替换测试（DSST）用于评估参与者的配对和自由回忆认知功能任务。参与者被问及关于过去30天参与休闲时间身体活动的开放式问题。对于每项活动，计算任务代谢当量 - 分钟 - 月。那些任务代谢当量 - 分钟 - 月达到或高于2000（相当于每周150分钟）的被定义为身体活跃。
在未调整的加权多变量线性回归模型中，达到中度至剧烈身体活动指南的人群（与未达到者相比）的DSST得分高8.3分（β = 8.3；95%置信区间：5.9 - 10.7；P < 0.001）。在调整年龄、性别、种族 - 族裔、吸烟状况、能量摄入、体重状况、高密度脂蛋白胆固醇、总胆固醇、胆固醇用药状况、糖化血红蛋白水平、糖尿病用药状况和血压用药状况后，达到中度至剧烈身体活动指南的人群（与未达到者相比）的DSST得分高6.23分（β = 6.23；95%置信区间：4.6 - 7.9；P < 0.001）。
在这个高血压老年人的全国样本中，达到身体活动指南与更高的认知功能相关。
