Ito K, Yukimura T, Takenaga T, Yamamoto K, Kangawa K, Matsuo H
Department of Pharmacology, Osaka City University Medical School, Japan.
Am J Physiol. 1988 Jun;254(6 Pt 1):G814-8. doi: 10.1152/ajpgi.1988.254.6.G814.
A synthetic alpha-human atrial natriuretic peptide (alpha-hANP) was infused into the renal artery of anesthetized dogs, and the urine flow, renal hemodynamics, and plasma guanosine 3',5'-cyclic monophosphate (cGMP) were determined. alpha-hANP led to a natriuresis accompanied by an increase in renal blood flow in the infused kidney but not in the contralateral kidney. The systemic blood pressure remained unchanged. The arterial plasma cGMP significantly increased after alpha-hANP administration. The plasma cGMP in the renal vein was significantly lower than that in the aorta throughout the experiment; therefore the elevated circulating cGMP was probably of extrarenal origin. The plasma cGMP in the right ventricle and femoral vein was also increased to the same extent seen in the aorta. On the other hand, plasma cGMP in the superior mesenteric vein was remarkably increased over that in the aorta. After the administration of alpha-hANP, the increased circulating cGMP seems to be the result of an enhancement of production of this nucleotide from the small intestine or organs drained by the superior mesenteric venous circulation.
将合成的α-人心房利钠肽（α-hANP）注入麻醉犬的肾动脉，测定尿流量、肾血流动力学和血浆鸟苷3',5'-环磷酸（cGMP）。α-hANP导致注入侧肾脏出现利钠作用，同时该侧肾血流量增加，而对侧肾脏无此变化。全身血压保持不变。给予α-hANP后，动脉血浆cGMP显著升高。在整个实验过程中，肾静脉中的血浆cGMP显著低于主动脉中的血浆cGMP；因此，循环中升高的cGMP可能来源于肾外。右心室和股静脉中的血浆cGMP也升高到与主动脉中相同的程度。另一方面，肠系膜上静脉中的血浆cGMP比主动脉中的显著升高。给予α-hANP后，循环中cGMP的升高似乎是由于小肠或由肠系膜上静脉循环引流的器官中该核苷酸生成增加所致。
