Fox Melanie D, Xiao Li, Zhang Miao, Kamat Ashish M, Siefker-Radtke Arlene, Zhang Li, Dinney Colin P, Czerniak Bogdan, Guo Charles C
Departments of Pathology.
Urology.
Am J Clin Pathol. 2017 May 1;147(5):500-506. doi: 10.1093/ajcp/aqx029.
Plasmacytoid urothelial carcinoma (PUC) of the bladder is a rare histologic variant. We retrospectively analyzed a large series of bladder PUC from a single institution.
The patients consisted of 44 men and five women with a mean age of 62 years (range, 45-86 years).
PUC was pure in 23 cases and mixed with other histologic types in 26 cases. All PUCs diffusely invaded the bladder wall. Most PUCs lacked immunoreactivity for the retinoblastoma (RB) gene protein (12/32) and E-cadherin (8/30). Of the 44 patients with follow-up information, 25 died of PUC at a mean of 23 months, whereas 19 patients were alive at a mean of 22 months.
Our findings support that bladder PUC is a highly aggressive disease. The lack of E-cadherin expression in PUCs may underlie the distinct discohesive histologic appearance, and abnormal function of the RB gene may be implicated in the development of PUC.
膀胱浆细胞样尿路上皮癌（PUC）是一种罕见的组织学变异类型。我们对来自单一机构的大量膀胱PUC病例进行了回顾性分析。
患者包括44名男性和5名女性，平均年龄62岁（范围45 - 86岁）。
23例为单纯PUC，26例与其他组织学类型混合。所有PUC均弥漫性侵犯膀胱壁。大多数PUC对视网膜母细胞瘤（RB）基因蛋白（12/32）和E - 钙黏蛋白（8/30）缺乏免疫反应性。在有随访信息的44例患者中，25例平均在23个月时死于PUC，而19例患者平均在22个月时仍存活。
我们的研究结果支持膀胱PUC是一种高度侵袭性疾病。PUC中E - 钙黏蛋白表达的缺乏可能是其独特的分散性组织学外观的基础，而RB基因的异常功能可能与PUC的发生有关。
