Alshahwan Mosaad I, Bin Dukhi Musaad M, Alotaibi Sultan N, Aldarrab Rakan, Alhefdhi Naif A, Al Oudah Nourah, Abumelha Saad
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU.
Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU.
Cureus. 2023 Mar 17;15(3):e36278. doi: 10.7759/cureus.36278. eCollection 2023 Mar.
This paper presents a case report of plasmacytoid variant urothelial carcinoma (PVUC), a rare form of transitional cell carcinoma. PVUC is known for its unique clinical features, aggressive behavior, and poor survival rates. PVUC comprises less than 3% of all bladder tumors, and its diagnosis is often difficult due to its resemblance to other forms of bladder cancer. It requires a staging workup to rule out metastasis, relies heavily on immunostaining and histopathological analysis for diagnosis, and requires a multidisciplinary approach with early aggressive treatment, including cisplatin-based chemotherapy following surgery. This report highlights the importance of understanding rare variants of bladder cancer to ensure timely and accurate diagnosis and appropriate treatment planning. We report here a case of a 75-year-old male with multiple comorbidities who presented with hematuria and was diagnosed with urothelial carcinoma plasmacytoid type, which was initially treated with transurethral resection but later found to be unresectable and treated with palliative chemotherapy and radiation therapy. Eventually, the patient passed away three years after the diagnosis.
本文报告了一例浆细胞样变异型尿路上皮癌（PVUC）病例，这是一种罕见的移行细胞癌形式。PVUC以其独特的临床特征、侵袭性生物学行为和较差的生存率而闻名。PVUC在所有膀胱肿瘤中占比不到3%，由于其与其他形式的膀胱癌相似，其诊断往往很困难。它需要进行分期检查以排除转移，诊断严重依赖免疫染色和组织病理学分析，并且需要多学科方法进行早期积极治疗，包括术后基于顺铂的化疗。本报告强调了了解膀胱癌罕见变异型以确保及时准确诊断和适当治疗规划的重要性。我们在此报告一例75岁男性，患有多种合并症，因血尿就诊，被诊断为浆细胞样型尿路上皮癌，最初接受经尿道切除术治疗，但后来发现无法切除，遂接受姑息性化疗和放射治疗。最终，患者在诊断三年后去世。
