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The lack of correlation between toxicity and free radical formation of two diaziridinyl benzoquinones.

作者信息

Lea J S, Garner H J, Butler J, Hoey B M, Ward T H

机构信息

Paterson Institute for Cancer Research, Christie Hospital, Holt Radium Institute, Manchester, U.K.

出版信息

Biochem Pharmacol. 1988 May 15;37(10):2023-5. doi: 10.1016/0006-2952(88)90551-5.

DOI:10.1016/0006-2952(88)90551-5
PMID:2837220
Abstract

L1210 and K562 leukaemic cells have been used to study the relationship between cytotoxicity and free radical production by two aziridinyl benzoquinones, 2,5-bis(carboethoxyamino)3,6-diaziridinyl-1,4-benzoquinone (AZQ) and 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinyl-1,4-benzoquinone (BZQ). BZQ showed a high level of toxicity in both cell lines, but no ESR signal was detectable, while AZQ readily produced an ESR signal but much lower cytotoxicity was observed, particularly in L1210 cells. The rate of superoxide formation was measured for each drug. The results demonstrate that cell killing and free radical production do not necessarily concur.

摘要

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